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ProteomicsProteasome resides in and dismantles plant heat stress granules constitutively
Stress granules (SGs) are conserved reversible cytoplasmic condensates enriched with aggregation-prone proteins assembled in response to various stresses. Defects in disassembly have been associated with various neuro- and muscular degenerative diseases in humans. Plants appear to have efficient app...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2024-08-22 | PXD044922 | Pride
Stress granules (sg) Proteasomes Heat stress Sg disassembly 
ProteomicsStress Granules FUS WT e FUS P525L
Stress Granules (SG) formation is a cellular protection mechanism, constituting a storage for untranslated mRNAs and RNA-binding proteins (RBPs); however, these condensates can turn into pathological aggregates, related to the onset of neurodegenerative diseases like Amyotrophic Lateral Sclerosis (A...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD049234 | Pride
Stress granules Als Rna-binding proteins Neurodegeneration Aggregation 
ProteomicsThe adaptor protein AP-3β disassembles heat-induced stress granules via 19S RP-associated deubiquitylation in Arabidopsis
To survive under adverse conditions, plants form stress granules (SGs) to temporally store mRNA and halt translation as a primary response. Dysregulation in SG disassembly can have detrimental effects on plant survival after stress release, yet the underlying mechanism remains poorly understood. Usi...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2025-01-24 | PXD058194 | Pride
Stress granules  ap-3β  tsn1/2  19s rp  deubiquitylation 
ProteomicsProtein and metabolite composition of Arabidopsis stress granules
• Stress granules (SGs) are evolutionary conserved aggregates of proteins and untranslated mRNAs formed in response to stress. Despite their importance for stress adaptation, no complete proteome composition has been reported for plant SGs. Herein, we addressed the existing gap. Importantly, we also...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2019-01-07 | PXD011716 | Pride
Cdka1 Arabidopsis thaliana Stress granules proteome Stress response Stress granule metabolome Affinity purification Stress granule extraction 
ProteomicsEndogenous retrovirus-like proteins recruit UBQLN2 to stress granules and shape their functional biology
The human genome is replete with sequences derived from foreign elements including endogenous retrovirus-like proteins of unknown function. The human genome is replete with sequences derived from foreign elements including endogenous retrovirus-like proteins of unknown function. Here we show that UB...
ORGANISM(S): Homo sapiens (Human) 
2025-06-04 | PXD061852 | Pride
Stress granules Retrotransposon-derived proteins Ubiquilins 
ProteomicsDiverse CMT2 neuropathies are linked to aberrant G3BP interactions in stress granules
Complex diseases often involve the interplay between genetic and environmental factors. Charcot-Marie-Tooth type 2 neuropathies (CMT2) are a group of genetically heterogeneous disorders, in which similar peripheral neuropathology is inexplicably caused by various mutated genes. Their possible molecu...
ORGANISM(S): Homo Sapiens 
2022-12-13 | PXD038754 |
MetabolomicsPKA regulates stress granule maturation to allow timely recovery after prolonged starvation
Cells have evolved multiple strategies to survive environmental stress conditions. This includes the formation of membrane-less cytoplasmic ribonucleoprotein structures called stress granules that sequester and protect mRNAs encoding many housekeeping genes. Stress granules are not static biomolecul...
2026-06-16 | MTBLS13923 | MetaboLights
ProteomicsPABPC1 stress granule interactome identified by BioID
Identification of Stress Granule interacting proteins by BioID (Roux et al., 2012) using PABPC1-BirA(R118G)-GFP construct
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD025334 | Pride
Stress granule Human Pabpc1 
ProteomicsProximity labeling and LC-MS/MS based identification of the stress granule microenvironment induced by different viruses
To dissect and compare the protein composition of stress granules formed during infections with two different RNA viruses as well as oxidative stress, we developed a recombinant mouse fibroblast cell line stably expressing a fusion protein of the stress granule marker G3BP1 with APEX2 and GFP. When ...
ORGANISM(S): Mus musculus (Mouse) 
2026-08-07 | PXD077432 | Pride
Proximity labeling Mouse hepatitis virus Semliki forest virus Stress granules 
ProteomicsNo evidence for the presence and control of tumor growth by stress granules in Kras mutant cancers
Stress granules (SG) are membraneless ribonucleoprotein-based cytoplasmic organelles that assemble in response to stress. Their formation is often associated with an almost global suppression of translation. Consequently, the aberrant assembly or disassembly of these granules has pathological implic...
ORGANISM(S): Mus musculus (Mouse) 
2024-09-24 | PXD053882 | Pride
Cancer Stress granules Kras 
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