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TranscriptomicsEnvironment-responsive transcription factors bind proto-silencer elements and regulate subtelomeric silencing
Subtelomeric chromatin is subject to evolutionarily conserved complex epigenetic regulation and is implicated in numerous aspects of cellular function including formation of heterochromatin, regulation of different stress response pathways, and control of lifespan. Subtelomeric DNA is characterized...
ORGANISM(S): Saccharomyces cerevisiae 
2011-05-02 | E-GEOD-21852 | biostudies-arrayexpress
ProteomicsNuclear pore complexes mediate subtelomeric gene silencing by regulating PCNA levels on chro atin
The nuclear pore complex (NPC) physically interacts with chromatin and regulates gene expression. The Saccharomyces cerevisiae inner ring nucleoporin Nup170 has been implicated in chromatin organization and the maintenance of gene silencing in subtelomeric regions. To gain insight into how Nup170 re...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2023-06-13 | PXD041496 | Pride
Nuclear pore complex Subtelomeric gene silencing Nup170 Nucleoporin Ctf18-rfc Pcna 
UnknownNuclear pore complexes mediate subtelomeric gene silencing by regulating PCNA levels on chromatin.
Not available
S-EPMC10292210 | biostudies-literature
UnknownEnvironment-responsive transcription factors bind subtelomeric elements and regulate gene silencing.
Not available
S-EPMC3049408 | biostudies-literature
GenomicsThe nucleoporin Nup170p is required for subtelomeric chromatin structure and gene silencing. [MNase-Seq]
Transcriptionally silent heterochromatin preferentially localizes at the nuclear periphery, but, despite this, certain budding yeast genes relocate to the nuclear periphery following gene activation, implicating the nuclear envelope in both transcriptional activation and silencing. It is unclear how...
ORGANISM(S): Saccharomyces cerevisiae 
2013-02-28 | E-GEOD-36792 | biostudies-arrayexpress
TranscriptomicsHistone H3K36 trimethylation is essential for multiple silencing mechanisms in fission yeast.
In budding yeast, Set2 catalyzes di- and trimethylation of H3K36 (H3K36me2 and H3K36me3) via an interaction between its SRI domain and C-terminal repeats of RNA polymerase II (Pol2) phosphorylated at Ser2 and Ser5 (CTD-S2,5-P). H3K36me2 recruits the Rpd3S histone deacetylase complex to repress crypt...
ORGANISM(S): Schizosaccharomyces pombe 
2016-02-04 | E-GEOD-66821 | biostudies-arrayexpress
UnknownSystematic profiling of subtelomeric silencing factors in budding yeast.
Not available
S-EPMC10542202 | biostudies-literature
UnknownHistone chaperone Chz1p regulates H2B ubiquitination and subtelomeric anti-silencing.
Not available
S-EPMC2836552 | biostudies-literature
TranscriptomicsRoles of mammalian Rap1 in TERT recruitment to chromatin, subtelomeric gene silencing and transcriptional regulation
Repressor-activator protein 1 (scRap1) is the major binding activity at Saccharomyces cerevisiae telomeres, with roles in telomere length regulation and establishment of subtelomeric silencing by recruiting the Sir proteins. scRap1 also acts as a transcription factor controlling the expression of ri...
ORGANISM(S): Mus musculus 
2010-07-10 | E-GEOD-19011 | biostudies-arrayexpress
TranscriptomicsGene deletion expression profiles of yeast chromatin modifiers
Packaging of DNA into chromatin has a profound impact on gene expression. To understand how changes in chromatin influence transcription, we analyzed 165 mutants of chromatin machinery components in Saccharomyces cerevisiae. mRNA expression patterns change in 80% of mutants, always with specific eff...
ORGANISM(S): Saccharomyces cerevisiae 
2011-05-23 | E-GEOD-25909 | biostudies-arrayexpress
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