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TranscriptomicsFoxO1 Controls Effector to Memory Transition and Maintenance of Functional CD8 T-Cell Memory
During a T cell response, naïve CD8 T cells differentiate into effector cells. Subsequently, a subset of effector cells termed memory precursor effector cells (MPECs) further differentiates into functionally mature memory CD8 T cells. The transcriptional network underlying this carefully scripted p...
ORGANISM(S): Mus musculus 
2013-06-25 | E-GEOD-45673 | biostudies-arrayexpress
ProteomicsIntrinsically disordered domain of transcription factor TCF-1 is required for T cell developmental fidelity
In development, pioneer transcription factors access silent chromatin to reveal lineage-specific gene programs. The structured DNA-binding domains of pioneer factors have been well characterized, but whether and how low-complexity intrinsically disordered regions (IDRs) affect chromatin and control ...
ORGANISM(S): Mus musculus (Mouse) 
2024-06-16 | PXD043586 | Pride
Tcf-1 T-cells L1 Transcription factor Idrs 
TranscriptomicsSingle cell RNA-seq of HLA-E restricted UL40-specific T cells
Human cytomegalovirus infection (CMV) can stimulate robust human leukocyte antigen (HLA)-E restricted CD8 T cell responses. These T cells recognize a peptide from UL40, which differs by as little as a single methyl group from self-peptides that also bind HLA-E, challenging their capacity to avoid se...
ORGANISM(S): Homo sapiens 
2021-05-21 | E-MTAB-10305 | biostudies-arrayexpress
ProteomicsThe CENP-T/-W complex is a binding partner of the histone chaperone FACT
The CENP-T/-W histone fold complex, as an integral part of the inner kinetochore, is essential for building a proper kinetochore at the centromere in order to direct chromosome segregation during mitosis. Notably, CENP-T/-W is not inherited at centromeres and new deposition is absolutely required at...
ORGANISM(S): Homo sapiens (Human) 
2016-06-14 | PXD004099 | Pride
Centromere Cenp Mitosis Histone chaperone 
UnknownProtective antifungal memory CD8(+) T cells are maintained in the absence of CD4(+) T cell help and cognate antigen in mice.
Not available
S-EPMC3287218 | biostudies-literature
UnknownFOXO3 regulates CD8 T cell memory by T cell-intrinsic mechanisms.
Not available
S-EPMC3280979 | biostudies-literature
UnknownT-bet is required for optimal proinflammatory CD4+ T-cell trafficking.
Not available
S-EPMC1895048 | biostudies-literature
Proteomics- Identification of Gαi2-interacting proteins via affinity pull-down and quantitative mass-spectrometry analysis.
In studying patients with activating GNAI2 mutations, we observed T cell hyperresponsiveness that was independent of cAMP suppression. Therefore, we hypothesized that Gαi2 utilizes alternative signal transduction pathways which might be delineated by identifying its interacting proteins in T cells. ...
ORGANISM(S): Homo sapiens (Human) Escherichia coli 
2024-09-20 | PXD048980 | Pride
Gpcrs G-protein coupled receptors Gnai2 - gαi2 G-protein 
UnknownTrypanosoma cruzi Reactivation After Chimeric Antigen Receptor T-Cell Therapy.
Not available
S-EPMC10804802 | biostudies-literature
UnknownMucosal Invariant T cells are Diminished in Very Early-Onset Inflammatory Bowel Disease.
Not available
S-EPMC8713142 | biostudies-literature
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