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ProteomicsA Bifunctional SPD-0090 contributes virulence of Streptococcus pneumoniae by affecting iron transport and galactose metabolism
Streptococcus pneumoniae (S.pneumoniae) is a Gram-positive bacterial pathogen that colonizes on the mucosal surfaces of the host's nasopharynx and upper respiratory tract and results in pneumonia. In order to survive and infect the host, S.pneumoniae must have obtain essential nutrients, such as tra...
ORGANISM(S): Streptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466) 
2022-06-01 | PXD030183 | Pride
Spd-0090 Virulence Iron transport protein Galactose metabolism Streptococcus pneumoniae 
UnknownNew ferrocenyl-containing organic hole-transporting materials for perovskite solar cells in regular (n-i-p) and inverted (p-i-n) architectures.
Not available
S-EPMC9059360 | biostudies-literature
ProteomicsQuantitative crotonylation proteomic analysis on Streptococcus pneumoniae
To further identify endogenous substrates of SPD_0839 and establish its regulatory network, quantitative proteomic analysis was performed on the spd_0839+ and p169 strains.
ORGANISM(S): Streptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466) 
2026-03-09 | PXD058867 | Pride
Crotonylation Lc-ms/ms Streptococcus pneumoniae 
ProteomicsSPD1590_iTRAQ - A Novel Iron Transporter SPD_1590 in Streptococcus pneumoniae Contributing to Bacterial Virulence Properties
Streptococcus pneumoniae has three main transporters for iron acquisition: PiaABC, PiuABC, and PitABC. Our previous study had shown that the mRNA and protein levels of SPD_1590 are significantly upregulated in a piuA/piaA/pitA triple mutant, suggesting that SPD_1590 might be a novel iron transporter...
ORGANISM(S): Streptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466) 
2018-08-08 | PXD008814 | Pride
Streptococcus pneumoniae d39 Itraq labeling Orbitrap fusion lumos 
ProteomicsImproved SILAC Method for Double Labeling of Bacterial Proteome
Stable isotope labeling with amino acids in cell culture (SILAC) is a robust proteomics method with the advantages of reproducibility and easy handling. This method is popular for the analysis of mammalian cells. However, amino acid conversion in bacteria decreases the labeling efficiency and quanti...
ORGANISM(S): Staphylococcus aureus 
2022-03-02 | PXD011221 | Pride
Proteomics Double labeling Bacteria Silac 
ProteomicsCiprofloxacin-resistant Staphylococcus aureus keeps resistance and virulence in Iron-restricted Condition
In summary, this study shows advantages of the CIP-R in the survival, drug resistance and virulence in iron restricted condition. DIA-based proteomics study combined with biochemical validation showed that CIP-R saves the energy by storing the glucose and increases the cell wall synthesis. Moreover,...
ORGANISM(S): Staphylococcus aureus 
2021-03-31 | PXD021692 | Pride
Proteomics Virulence Iron-restricted Staphylococcus aureus 
ProteomicsImproved SILAC Method for Double Labeling of Bacterial Proteome
Stable isotope labeling with amino acids in cell culture (SILAC) is a robust proteomics method with the advantages of reproducibility and easy handling. This method is popular for the analysis of mammalian cells. However, amino acid conversion in bacteria decreases the labeling efficiency and quanti...
ORGANISM(S): Escherichia coli Staphylococcus aureus 
2022-02-28 | PXD011244 | Pride
Proteomics Double labeling Bacteria Silac 
ProteomicsPotential Role of Lysine Acetylation in Antibiotic Resistance of Escherichia coli
Antibiotic resistance is increasingly becoming a serious challenge to public health. The regulation of metabolism by post-translational modifications (PTMs) has been widely studied; however, the comprehensive mechanism underlying the regulation of acetylation in bacterial resistance against antibiot...
ORGANISM(S): Escherichia coli str. K-12 substr. MG1655 
2022-10-14 | PXD030283 | Pride
Post-translational modification  escherichia coli  acetylation  pykf  antibiotic resistance 
ProteomicsProteomic Analysis on the Mechanism of Iron-Compensation Substitute for Manganese Deficiency of Streptococcus pneumoniae
Iron (Fe) and Manganese (Mn) are essential for bacterial survival and virulence as they are involved in catalysis, infection and biofilm formation. The basal metabolism of pathogenic bacteria would be disturbed by the deficiency of metal ions in the host environment. In this study, we found that Str...
ORGANISM(S): Streptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466) 
2023-09-30 | PXD008652 | Pride
Manganese deficiency Iron-compensation Proteomic Streptococcus pneumoniae 
ProteomicsAcetylome analysis of Streptococcus pneumoniae
Our dataset provides the first system-wide analysis of lysine acetylation in S. pneumoniae.
ORGANISM(S): Streptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466) 
2018-01-29 | PXD007687 | Pride
Acetylome Lysine acetylation Streptococcus pneumoniae Ptm 
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