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ProteomicsSurface proteomics reveals CD72 as a target for in vitro-evolved nanobody-based CAR-T cells in refractory B-cell malignancies
Alternate strategies are needed for B-cell malignancy patients relapsing after CD19-targeted immunotherapy. Here, integrated cell surface proteomics and epigenetic analysis initially revealed CD72 as an optimal target for poor-prognosis MLL-rearranged B-ALL, which we further found to be expressed wi...
ORGANISM(S): Homo sapiens (Human) 
2022-02-15 | PXD016800 | Pride
B-all Cell surface Cd72 
TranscriptomicsCITE-seq of 52 matched primary AML samples from diagnosis and relapse
CITE-seq was used to interrogate transcriptomic and surface immunophenotype heterogeneity at diagnosis and relapse. This experiment reveals cell state evolution of AML blasts at two timepoints and provides new therapeutic avenues for targeting surface antigens in AML.
ORGANISM(S): Homo sapiens 
2026-01-12 | E-MTAB-16321 | biostudies-arrayexpress
ProteomicsRepurposing E3 ubiquitin ligases as cell surface protein degraders using Proteolysis Targeting Antibodies
The majority of current therapeutics targeting plasma membrane receptors function by antagonizing ligand binding or enzymatic activities. Typical mammalian proteins, however, consist of multiple domains executing discrete but coordinated activities, and saturating inhibition of one functional domain...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-05-25 | MSV000089542 | MassIVE
TranscriptomicsTranscriptional responses of mouse BMM and TEPM to lipopolysaccharide (LPS)
Evolutionary change in gene expression is generally considered to be a major driver of phenotypic differences between species. We investigated innate immune diversification by analyzing inter-species differences in the transcriptional responses of primary human and mouse macrophages to the TLR4 agon...
ORGANISM(S): Mus musculus 
2012-03-28 | E-GEOD-19490 | biostudies-arrayexpress
TranscriptomicsTranscriptional responses of human monocyte-derived macrophages (HMDM) to lipopolysaccharide (LPS)
Evolutionary change in gene expression is generally considered to be a major driver of phenotypic differences between species. We investigated innate immune diversification by analyzing inter-species differences in the transcriptional responses of primary human and mouse macrophages to the TLR4 agon...
ORGANISM(S): Homo sapiens 
2012-03-28 | E-GEOD-19482 | biostudies-arrayexpress
ProteomicsOrganelle resolved proteomics reveals new chordoma cell surface markers required for proliferation and association with outcome
Here, we used a proteomics approach to identify novel chordoma-specific cell-surface protein markers. Four established chordoma cell lines (U-CH17P, U-CH17M, U-CH17S and U-CH11R) were analyzed by quantitative proteomics using a comprehensive organellar fractionation approach based on differential ul...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-03-31 | MSV000089171 | MassIVE
UnknownRapidly Adaptive All-covalent Nanoparticle Surface Engineering.
Not available
S-EPMC8362155 | biostudies-literature
TranscriptomicsTranscriptome dynamics of developing photoreceptors in 3-D retina cultures recapitulates temporal sequence of human cone and rod differentiation revealing cell surface markers and gene networks
To define molecular mechanisms underlying rod and cone differentiation, we generated H9 human embryonic stem cell line carrying a GFP reporter that is controlled by the promoter of cone-rod homeobox (CRX) gene, the first known marker of post-mitotic photoreceptor precursors. CRXp-GFP reporter in H9 ...
ORGANISM(S): Homo sapiens 
2015-08-03 | E-GEOD-67645 | biostudies-arrayexpress
ProteomicsProteomic analysis of the pathogen surface in cholera identifies host proteins involved in defense and microbiota recognition
The microbial cell surface is a critical site of microbe-host interactions that often control infection outcomes. Defining the set of host proteins present at this interface has been challenging. Here, we used a surface biotinylation approach coupled to quantitative mass spectrometry to identify and...
ORGANISM(S): Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) Oryctolagus cuniculus (Rabbit) 
2021-10-02 | PXD027076 | Pride
Oryctolagus cuniculus Vibrio cholerae 
UnknownThe Importance of Non-accessible Crosslinks and Solvent Accessible Surface Distance in Modeling Proteins with Restraints From Crosslinking Mass Spectrometry.
Not available
S-EPMC4937519 | biostudies-literature
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