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ProteomicsLight-mediated discovery of surfaceome nanoscale organization and intercellular receptor interaction networks
Delineating the extracellular interaction network of the cell surface proteotype (the surfaceome) is fundamental to understanding cellular signaling function in health and disease. Here, we developed LUX-MS, an optoproteomic technology that enables the spatiotemporal and proteome-wide study of surfa...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) Listeria monocytogenes serotype 4b Listeria phage A500 Escherichia coli 
2021-06-14 | PXD020481 | Pride
Lc-ms/ms 
ProteomicsAerobic Adaptation and Metabolic Dynamics of Propionibacterium freudenreichii DSM 20271: Insights from Comparative Transcriptomics and Surfaceome Analysis
Propionibacterium freudenreichii (PFR) DSM 20271 is a bacterium known for its ability to thrive in diverse environments and produce vitamin B12. Despite its anaerobic preference, recent studies have elucidated its ability to prosper in the presence of oxygen, prompting a deeper exploration of its ph...
ORGANISM(S): Propionibacterium freudenreichii subsp. freudenreichii 
2024-09-09 | PXD051703 | Pride
Vitamin b12 Aerobic adaptation Surfaceome analysis Propionibacterium freudenreichii 
ProteomicsUltrafast and Chemoselective Biotinylation of Living Cell Surface for Time-Resolved Surfaceome Analysis - final
Cell surface proteins participate in many important biological processes such as cell-to-cell interaction, signal transduction, cell adhesion, and protein transportation. In-depth study of the cell surface protein group is of great significance. Nevertheless, detection and analysis of the surfaceome...
ORGANISM(S): Homo Sapiens 
PXD053733 |
ProteomicsHeart surfaceome profiling using biotin capture
Cell surface proteins (surfaceome) represent key signalling and interaction molecules for therapeutic targeting, biomarker profiling, and cellular phenotyping. Understanding the surfaceome of complex tissues including the heart is essential to investigate membrane composition and function in physiol...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
MSV000095912 | MassIVE
ProteomicsSurfaceome dynamics and surface trafficking during neuronal development and synaptic plasticity
Surface proteins are of fundamental importance for formation of synaptic connections and activity-dependent plasticity. Here, we used a spatiotemporally resolved cell-surface proteotype analysis to characterize the neuronal surface-exposed proteome, or surfaceome, during neuronal development and syn...
ORGANISM(S): Rattus norvegicus (Rat) 
2020-10-05 | PXD014790 | Pride
Synapse Surface Neuroproteomics Spatial Surfaceome 
ProteomicsThe surfaceome of chondrogenic cells
Chondrogenesis, the process through which cartilage forms, has implications for cartilage repair and osteoarthritis (OA) management. In this study, we present the first comprehensive quantitative analysis of the surfaceome of chondrogenic cells using a well-established in vitro chondrogenic model. B...
ORGANISM(S): Gallus gallus (Chicken) 
2026-01-19 | PXD064013 | Pride
Glycocapture Osteoarthritis Cartilage Surfaceome  chondrogenesis Cartilage regeneration 
ProteomicsSurfaceome proteomic of glioblastoma revealed potential targets for immunotherapy
Glioblastoma (GBM) is the most common and devastating malignant brain tumor in adults. The mortality rate is very high despite different treatments. New therapeutic targets are therefore highly needed to improve patient care. Cell-surface proteins represent attractive targets due to their accessibil...
ORGANISM(S): Homo sapiens (Human) 
2021-11-03 | PXD027110 | Pride
Surface proteins Glioblastoma Mutated proteins Surfaceome Immunotherapy 
ProteomicsThe Leucegene AML surfaceome atlas: immunotherapeutic target identification in AML
We exploited the extensive genomic diversity of the Leucegene cohort of primary human AML specimens to provide an overview of the human AML surfaceome. Due to high cell number requirements, surface proteomics has been underexploited in AML so far, although surface proteome analysis of AML cell lines...
ORGANISM(S): Homo sapiens (Human) 
2024-05-21 | PXD043772 | Pride
Acute myeloid leukemia Surfaceome Pan-aml antigens 
GenomicsSurfaceome analysis of extracellular vesicles from senescent cells uncovers uptake repressor DPP4
Surfaceome analysis of extracellular vesicles from senescent cells uncovers uptake repressor DPP4
PRJNA889766 | ENA
GenomicsImmunotherapeutic targeting of surfaceome heterogeneity in AML
Immunotherapeutic targeting of surfaceome heterogeneity in AML
PRJNA1010863 | ENA
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