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ProteomicsEpigenetic mechanisms to propagate histone acetylation by p300/CBP
Histone acetylation is important for the activation of gene transcription but little is known about its direct ‘read/write’ mechanisms. Here, we report cryo-electron microscopy structures in which a p300/CBP multidomain monomer recognizes histone H4 N-terminal tail (NT) acetylation (ac) in a nucleos...
ORGANISM(S): Homo sapiens (Human) 
2023-05-08 | PXD040835 | Pride
P300/cbp Histone Acetylation 
ProteomicsOvercoming off-targets: Assessing western blot signals for Bcnt/Cfdp1, a tentative component of the chromatin remodeling complex
The mammalian Bucentaur/Craniofacial developmental protein 1 (Bcnt/Cfdp1) is a tentative component of the Srcap (SNF2-Related CBP Activator Protein) chromatin remodeling complex, but little is known about its properties, partly because few antibodies are available to detect the endogenous protein.　W...
ORGANISM(S): Mus musculus (Mouse) 
2020-08-03 | PXD019016 | Pride
Bcnt 
ProteomicsGlycometabolic regulation of the biogenesis of small extracellular vesicles
The biogenesis of small extracellular vesicles (sEVs) is regulated by multiple molecular machineries, generating considerably heterogeneous vesicle populations, i.e., exosomes and non-exosomal vesicles, with distinct cargo molecules. However, the role of carbohydrate metabolism in generating such ve...
ORGANISM(S): Mus musculus (Mouse) 
2020-10-14 | PXD020670 | Pride
Exosome 
ProteomicsPolyamines stimulate the protein synthesis of the initiation factor eIF5A2 participating in mRNA decoding distinct from eIF5A1
Polyamines are present in all living organisms, and their homeostasis is closely associated with human health and disease. Further, they are small aliphatic cations that exhibit multifunctional activities through interactions with acidic substances, thereby precluding our understanding of their mole...
ORGANISM(S): Homo sapiens (Human) 
2025-08-25 | PXD063151 | Pride
Polyamine Proteomics Eukaryotic initiation factor 5a (eif5a) Cell proliferation Spermidine 
ProteomicsStructural basis for antiepileptic drugs and botulinum neurotoxin recognition of SV2A
More than one percent of people have epilepsy worldwide. Levetiracetam (LEV) is a successful new-generation antiepileptic drug (AED), and its derivative, brivaracetam (BRV), shows improved efficacy. Synaptic vesicle glycoprotein 2a (SV2A), a putative membrane transporter in the synaptic vesicles (SV...
ORGANISM(S): Homo sapiens (Human) 
2024-06-23 | PXD050355 | Pride
Bont Lev Sv2a Aed 
ProteomicsDisruption of endothelial glycocalyx after ischemic stroke onset: Activated scission activity of proHPSE by acrolein exposure
Infiltration of peripheral immune cells after blood-brain barrier (BBB) dysfunction causes severe inflammation after a stroke. Although the endothelial glycocalyx functions as a barrier to circulating cells, the relationship between stroke severity and glycocalyx dysfunction remains unclear. In this...
ORGANISM(S): Homo sapiens (Human) 
2020-11-16 | PXD021040 | Pride
Acrolein heparanase 
ProteomicsAsparagine-linked glycosylation mediates glucose sensing for cell fate decision
Asparagine-linked glycosylation (N-glycosylation), a fundamental modification of proteins synthesized in the endoplasmic reticulum, is easily suppressed by glucose deprivation, but the role of this metabolic link has long remained unclear. We previously identified the activity of mannose metabolism,...
ORGANISM(S): Homo sapiens (Human) 
2026-03-02 | PXD066382 | Pride
Metabolism Cell fate decision Glucose deprivation N-glycosylation Unfolded protein response 
ProteomicsRegulation of mammalian 3D genome organization and histone H3K9 dimethylation by H3K9 methyltransferases
Histone H3 lysine 9 dimethylation (H3K9me2) is a highly conserved silencing epigenetic mark. Chromatin marked with H3K9me2 forms large domains in mammalian cells and overlaps well with lamina-associated domains and the B compartment defined by Hi-C. However, the role of H3K9me2 in 3-dimensional (3D)...
ORGANISM(S): Mus musculus (Mouse) 
2021-08-05 | PXD024756 | Pride
Histone h3 methylation 
ProteomicsExpression of spider silk in tobacco improves drought tolerance with minimal effects on its mechanotype
Spider silk, especially dragline silk from Trichonephila clavipes, is an excellent natural material with remarkable mechanical properties. In this study, we generated nucleus- and plastid-encoded expression of a partial sequence of one of the components of dragline silk, major ampullate spidroin-1 (...
ORGANISM(S): Nicotiana tabacum (Common tobacco) 
2025-05-06 | PXD040180 | Pride
Spider silk Tensile strength Drought tolerance Glycine-rich Aba 
ProteomicsIdentification of Distinct N-Glycosylation Patterns on Extracellular Vesicles from Small-Cell and Non-Small-Cell Lung Cancer Cells
Asparagine-linked glycosylation (N-glycosylation) of proteins in the cancer secretome has gained increasing attention as a potential biomarker for cancer detection and diagnosis. Small extracellular vesicles (sEVs) constitute a large part of the cancer secretome, yet little is known about whether th...
ORGANISM(S): Homo sapiens (Human) 
2022-06-09 | PXD030865 | Pride
Human cancer small extracellular vesicles 
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