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ProteomicsMammalian Bcnt/Cfdp1, a potential epigenetic factor characterized by an acidic stretch in the disordered N-terminal and S250 phosphorylation in the conserved C-terminal regions
The function of mammalian Bcnt protein is poorly understood yet, though Bcnt homologs (yeast Swc5 and Dorsophila Yeti) play crucial roles in chromatin remodeling organization. In this study, we found that mammalian Bcnt protein shows unusual mobility on SDS-PAGE and is acetylated in vitro by CREB-bi...
ORGANISM(S): Homo sapiens (Human) 
2015-06-25 | PXD002228 | Pride
Q exactive Homo sapiens 
ProteomicsEpigenetic mechanisms to propagate histone acetylation by p300/CBP
Histone acetylation is important for the activation of gene transcription but little is known about its direct ‘read/write’ mechanisms. Here, we report cryo-electron microscopy structures in which a p300/CBP multidomain monomer recognizes histone H4 N-terminal tail (NT) acetylation (ac) in a nucleos...
ORGANISM(S): Homo sapiens (Human) 
2023-05-08 | PXD040835 | Pride
P300/cbp Histone Acetylation 
ProteomicsOvercoming off-targets: Assessing western blot signals for Bcnt/Cfdp1, a tentative component of the chromatin remodeling complex
The mammalian Bucentaur/Craniofacial developmental protein 1 (Bcnt/Cfdp1) is a tentative component of the Srcap (SNF2-Related CBP Activator Protein) chromatin remodeling complex, but little is known about its properties, partly because few antibodies are available to detect the endogenous protein.　W...
ORGANISM(S): Mus musculus (Mouse) 
2020-08-03 | PXD019016 | Pride
Bcnt 
ProteomicsGlycometabolic regulation of the biogenesis of small extracellular vesicles
The biogenesis of small extracellular vesicles (sEVs) is regulated by multiple molecular machineries, generating considerably heterogeneous vesicle populations, i.e., exosomes and non-exosomal vesicles, with distinct cargo molecules. However, the role of carbohydrate metabolism in generating such ve...
ORGANISM(S): Mus musculus (Mouse) 
2020-10-14 | PXD020670 | Pride
Exosome 
ProteomicsComparative Proteomics of HepG2 Cells Reveals NGLY1 as an Important Regulator of Ferroptosis Resistance and Iron Uptake
NGLY1 deficiency is a rare genetic disorder caused by mutations in the NGLY1 gene. This disorder presents a wide range of clinical symptoms, and its severity varies among affected individuals. Previous studies have focused on understanding the influence of NGLY1 on energy metabolism, revealing dysre...
ORGANISM(S): Homo sapiens (Human) 
2025-07-18 | PXD058551 | Pride
Ferroptosis Hepg2 cells Ngly1 deficiency Iron metabolism 
ProteomicsSTING signalling is terminated through ESCRT-dependent microautophagy of vesicles originating from recycling endosomes
Stimulator of interferon genes (STING) is essential for the type I interferon response against a variety of DNA pathogens. Upon emergence of cytosolic DNA, STING translocates from the endoplasmic reticulum (ER) to the Golgi where STING activates the downstream kinase TBK1, then to lysosome through r...
ORGANISM(S): Mus musculus (Mouse) 
2023-01-24 | PXD039411 | Pride
Microautophagy Sting Escrt 
ProteomicsThe methyltransferase METTL9 mediates pervasive 1-methylhistidine modification in mammalian proteomes
Post-translational methylation plays a crucial role in regulating and optimizing protein function. Protein histidine methylation, occurring as the two isomers 1- and 3- methylhistidine (1MH and 3MH), was first reported five decades ago, but remains largely unexplored. Here we report that METTL9 is a...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2020-11-23 | PXD022067 | Pride
Metylation histidine mettl9 
ProteomicsPolyamines stimulate the protein synthesis of the initiation factor eIF5A2 participating in mRNA decoding distinct from eIF5A1
Polyamines are present in all living organisms, and their homeostasis is closely associated with human health and disease. Further, they are small aliphatic cations that exhibit multifunctional activities through interactions with acidic substances, thereby precluding our understanding of their mole...
ORGANISM(S): Homo sapiens (Human) 
2025-08-25 | PXD063151 | Pride
Polyamine Proteomics Eukaryotic initiation factor 5a (eif5a) Cell proliferation Spermidine 
ProteomicsStructural basis for antiepileptic drugs and botulinum neurotoxin recognition of SV2A
More than one percent of people have epilepsy worldwide. Levetiracetam (LEV) is a successful new-generation antiepileptic drug (AED), and its derivative, brivaracetam (BRV), shows improved efficacy. Synaptic vesicle glycoprotein 2a (SV2A), a putative membrane transporter in the synaptic vesicles (SV...
ORGANISM(S): Homo sapiens (Human) 
2024-06-23 | PXD050355 | Pride
Bont Lev Sv2a Aed 
ProteomicsDevelopmental dynamics of the postsynaptic proteome to understand synaptic maturation and dysmaturation
The postsynaptic density (PSD) is a protein condensate composed of ~1,000 proteins beneath the postsynaptic membrane of excitatory synapses. The number, shape, and plasticity of synapses are altered during development. However, the dynamics of synaptic protein composition across development have not...
ORGANISM(S): Mus musculus (Mouse) Callithrix jacchus 
2024-01-17 | PXD048549 | Pride
Brain postsynaptic density mouse primate 
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