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MetabolomicsDifferent regions of synaptic vesicle membrane regulate VAMP2 conformation for the SNARE assembly
Vesicle associated membrane protein 2 (VAMP2/synaptobrevin2), a core SNARE protein residing on synaptic vesicles (SVs), forms helix bundles with syntaxin-1 and SNAP25 for the SNARE assembly. Prior to the SNARE assembly, the structure of VAMP2 is unclear. Here, by using in-cell NMR spectroscopy, we d...
2021-10-06 | MTBLS1503 | MetaboLights
GenomicsTranscriptomic profiling and electrophysiological analysis from microtransplanted synaptic membranes
Transcriptomic profiling and electrophysiological analysis from microtransplanted synaptic membranes
PRJNA932036 | ENA
ProteomicsCross-linking mass spectrometry uncovers protein interactions and functional assemblies in synaptic vesicle membranes
Synaptic vesicles are storage organelles for neurotransmitters in the pre-synaptic cytosol. When an action potential arrives at the pre-synaptic terminal, they fuse with the pre-synaptic membrane and neurotransmitters are released. In this project, we set out to study the protein interactions formed...
ORGANISM(S): Rattus norvegicus (Rat) 
2020-12-09 | PXD020859 | Pride
Chemical cross-linking Mass spectrometry Protein networks Synaptic vesicles Synaptophysin Synaptobrevin-2 
ProteomicsBeta-synuclein potentiates synaptic vesicle dopamine uptake and rescues dopaminergic neurons from MPTP-induced death in the absence of other synucleins
Previous studies have demonstrated an importance of alpha-synuclein as a modulator of various mechanisms implicated in chemical neurotransmission but information about other two synuclein family members’ involvement in molecular processes taking place in presynaptic terminals is limited. Here we dem...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-17 | PXD027786 | Pride
Dopamine Synapse Mptp toxicity Synuclein Transgenic mice Dopaminergic neurons Parkinson’s disease Vesicles Neurodegenerative disease Neurotransmitter vesicular uptake 
ProteomicsAltered GM1 catabolism affects NMDAR-mediated Ca2+ signaling at ER-PM junctions and increases synaptic spine formation
GM1-ganglioside, an abundant GSL in neuronal membranes, is integral to ER-PM junctions where it interacts with synaptic proteins/receptors and regulates Ca2+ signaling.
ORGANISM(S): Mus musculus (Mouse) 
2024-03-19 | PXD042994 | Pride
Membrane contact sites (mcs) Glycosphingolipids (gsls) Proteomics 
TranscriptomicsTranscriptomic profiling and electrophysiological analysis from microtransplanted synaptic membranes
Alterations of synaptic function in individuals with schizophrenia have been found in transcriptomics, proteomics, and genome wide association studies. Impaired synaptic glutamatergic (excitatory) and GABAergic (inhibitory) neurotransmission in affected brain regions (e.g. dorsolateral prefrontal co...
ORGANISM(S): Homo sapiens 
2023-03-20 | GSE224683 | GEO
ProteomicsDynamics of the mouse brain cortical synaptic proteome during postnatal brain development
Development of the brain involves the formation and maturation of numerous synapses. This process requires prominent changes of the synaptic proteome and potentially involves thousands of different proteins at every synapse. To date the proteome analysis of synapse development has been studied spars...
ORGANISM(S): Mus musculus (Mouse) 
2018-10-26 | PXD004129 | Pride
Mouse Development Postnatal Cortex 
Unknownα-Synuclein interacts directly with AP2 and regulates its binding to synaptic membranes.
Not available
S-EPMC12143788 | biostudies-literature
ProteomicsAnalysis of pre-and postsynaptic brain receptors, transporters and channels by mass spectrometry
Although receptors, transporters and channels (RTCs) are key elements in the synaptic membrane, work on analysis and quantification of RTCs by mass spectrometry is limited. Additionally, there is not a single mass spectrometrical study that assigns the localisation of RTCs to the pre- or post-synap...
ORGANISM(S): Rattus norvegicus (Rat) 
2016-12-12 | PXD001948 | Pride
Transporters and channels Presynaptic Receptors Postsynaptic Membrane 
UnknownCross-linking mass spectrometry uncovers protein interactions and functional assemblies in synaptic vesicle membranes.
Not available
S-EPMC7870876 | biostudies-literature
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