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ProteomicsIdentification of synaptic DGKq interactors that stimulate DGKq activity
Lipids and their metabolic enzymes are a critical point of regulation for the membrane curvature required to induce membrane fusion during synaptic vesicle recycling. One such enzyme is diacylglycerol kinase theta (DGKq), which produces phosphatidic acid (PtdOH) that generates negative membrane curv...
ORGANISM(S): Rattus norvegicus (Rat) 
2021-12-18 | PXD030495 | Pride
Lc-msms Apex2 Dgk Syt1 
TranscriptomicsSuppression of NCALD protects against spinal muscular atrophy by restoring impaired endocytosis
Spinal muscular atrophy (SMA) is a common genetic motor neuron (MN) disease caused by low levels of the ubiquitously expressed housekeeping survival motor neuron (SMN) protein, whereas concomitant overexpression of plastin 3 (PLS3) protects from SMA. Here we identify neurocalcin delta (NCALD), a neu...
ORGANISM(S): Homo sapiens 
2015-01-01 | E-GEOD-58316 | biostudies-arrayexpress
UnknownClathrin coat controls synaptic vesicle acidification by blocking vacuolar ATPase activity.
Not available
S-EPMC5935483 | biostudies-literature
ProteomicsControl of synaptic vesicle release probability via VAMP4 targeting to endolysosomes
The probability of synaptic vesicle (SV) fusion in response to an action potential, termed vesicular release probability (Pr), is a stochastic but tightly regulated process. SNARE proteins are the molecular executors of SV fusion and therefore, key modulators of Pr. The non-canonical SNARE VAMP4 is ...
ORGANISM(S): Mus musculus (Mouse) 
2021-03-11 | PXD021437 | Pride
Endosome Neurotransmitter Synaptic plasticity Release probability Vamp4 Lysosome Synaptic vesicle Endocytosis 
UnknownSynaptobrevin-2 dependent regulation of single synaptic vesicle endocytosis.
Not available
S-EPMC8684713 | biostudies-literature
UnknownTRPM7 is critical for short-term synaptic depression by regulating synaptic vesicle endocytosis.
Not available
S-EPMC8516418 | biostudies-literature
UnknownControl of synaptic vesicle endocytosis by an extracellular signalling molecule.
Not available
S-EPMC3778765 | biostudies-literature
UnknownHigh- and low-mobility stages in the synaptic vesicle cycle.
Not available
S-EPMC2905121 | biostudies-literature
UnknownSynaptophysin regulates the kinetics of synaptic vesicle endocytosis in central neurons.
Not available
S-EPMC3136197 | biostudies-literature
UnknownBeta-amyloid disrupted synaptic vesicle endocytosis in cultured hippocampal neurons.
Not available
S-EPMC1993833 | biostudies-literature
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