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ProteomicsSyndecan liver cancer nanoHPLC-MS/MS results
Liver cancer was induced in mouse model organisms with diethylnitrosamine. It was found the the introduction of human Syndecan significantly slowed down the carcinogenesis. The proteomic profile of the syndecan treated livers proved to be significantly different from the non-treated samples. Details...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2021-01-09 | MSV000086679 | MassIVE
ProteomicsThe cardiac syndecan-4 interactome:A role for syndecan-4 innuclear translocation of muscle LIM protein (MLP)
Biomechanical stimuli and extracellular matrix cues are important initiators for the cardiac remodeling process, and signaling hubs in the sarcolemma are important contact points between the extracellular space and cell interior, sensing and transducing biomechanical signals into a cellular response...
ORGANISM(S): Rattus norvegicus (Rat) 
2019-04-09 | PXD011249 | Pride
Hypertrophy Heart Csrp3 Syndecan-4 Interactome Mlp Nuclear translocation Biomechanical stress 
TranscriptomicsSyndecan-2 and apoptosis in osteosarcoma
Syndecan-2 was found to act as a tumor suppressor in osteosarcoma and to mediate the apoptotic response to cytotoxic agents. To determine new mechanisms that control cell survival and apoptosis in osteosarcoma cells, we aim to show target genes that are involved downstream of this proteoglycan durin...
ORGANISM(S): Homo sapiens 
2013-09-23 | E-GEOD-19913 | biostudies-arrayexpress
ProteomicsSyndecan-2 partners in rat left ventricular lysates
To get more insight into the role of syndecan-2, we here sought to identify interaction partners of syndecan-2 in rat left ventricle. By using three different affinity purification methods combined with mass spectrometry (AP-MS) analysis, we identified 30 novel partners and 9 partners previously des...
ORGANISM(S): Rattus norvegicus (Rat) 
2020-12-01 | PXD018942 | Pride
Mass spectrometry Syndecan-2 Interactome 
ProteomicsSyndecan-4 is a maestro of gastric cancer cell invasion and communication that underscores poor survival
Gastric cancer is a dominating cause of cancer-associated mortality with limited therapeutic options. Here, we show that syndecan-4 (SDC4), a plasma membrane proteoglycan, is highly expressed in intestinal subtype gastric tumours and that this signature associates with patients’ poor survival. Furth...
ORGANISM(S): Homo sapiens (Human) 
2023-05-05 | PXD035679 | Pride
Extracellular vesicles Extracellular communication Gastric cancer Syndecan-4 Heparan sulfate proteoglycans Cancer cell invasion 
UnknownThe cardiac syndecan-4 interactome reveals a role for syndecan-4 in nuclear translocation of muscle LIM protein (MLP).
Not available
S-EPMC6552415 | biostudies-literature
UnknownCleavage of syndecan-4 by ADAMTS1 provokes defects in adhesion.
Not available
S-EPMC3807939 | biostudies-literature
UnknownSyndecan-1 downregulates syndecan-4 expression by suppressing the ERK1/2 and p38 MAPK signaling pathways in cultured vascular endothelial cells.
Not available
S-EPMC8099740 | biostudies-literature
UnknownHeparan sulfate chain valency controls syndecan-4 function in cell adhesion.
Not available
S-EPMC2863221 | biostudies-literature
UnknownSyndecan-4/PAR-3 signaling regulates focal adhesion dynamics in mesenchymal cells.
Not available
S-EPMC7433185 | biostudies-literature
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