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TranscriptomicsModulation of the TNF-induced macrophage response by synovial fibroblasts
Here we explored how the human macrophage response to tumor necrosis factor (TNF) is regulated by human synovial fibroblasts, the representative stromal cell type in the synovial lining of joints that become activated during inflammatory arthritis. Genome-wide transcriptome analysis (RNAseq) showed ...
ORGANISM(S): Homo sapiens 
2014-08-04 | E-GEOD-57723 | biostudies-arrayexpress
ProteomicsProteomic analysis of synovial fibroblasts from patients with Juvenile idiopathic arthritis
The aim was to characterize the proteomic alterations in synovial fibroblasts from patients with juvenile idiopathic arthritis, with or without prior priming with inflamed synovial fluid. Synovial fibroblasts were isolated from the synovial fluid of patients with oligoarticular juvenile idiopathic a...
ORGANISM(S): Homo sapiens (Human) 
2026-04-13 | PXD041459 | Pride
Synovial fluid Inflammation Juvenile idiopathic arthritis Synovial fibroblasts 
TranscriptomicsTranscriptional analysis of normal and pathological synovial fibroblasts
The aim of this study was to compare gene expression between two pathological groups of human synovial fibroblasts (SF) from rheumatoid arthritis (RA) and osteoarthritis (OA) synovial tissues with normal SF from healthy individuals (HSF). We used microarray expression profiling in SF cultured from ...
ORGANISM(S): Homo sapiens 
2011-10-24 | E-GEOD-29746 | biostudies-arrayexpress
TranscriptomicsTranscriptional response to hypoxia of normal and rheumatoid arthritis synovial fibroblasts
Inflammatory tissues are characterized by low oxigen concentrations (hypoxia). These conditions are very different from that usually present in tissue cultures where transcriptomic profiles of human fibroblasts from inflammatory tissues have been previously analysed. The aim of this study was to cha...
ORGANISM(S): Homo sapiens 
2010-12-10 | E-GEOD-21959 | biostudies-arrayexpress
TranscriptomicsSingle cell RNA-sequencing of the human synovium in inflammatory arthritis
The study presents: - an optimized synovium dissociation protocol for single cell RNA-sequencing studies of the human synovium. The protocol enables the isolation of high yield of viable synovial cells from prospectively collected fresh synovial biopsies from patients with inflammatory arthritis wi...
ORGANISM(S): Homo sapiens 
2024-04-21 | E-MTAB-11791 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human synovial fibroblasts from rheumatoid arthritis and osteoarthritis patients
mRNA expression levels in synovial fibroblasts in 6 rheumatoid arthritis patients versus 6 osteoarthritis patients. Experiment Overall Design: Synovial tissue was obtained from open joint replacement surgery or Experiment Overall Design: arthroscopic synovectomy. Patients with RA or OA (n = 6 each...
ORGANISM(S): Homo sapiens 
2009-04-28 | E-GEOD-7669 | biostudies-arrayexpress
TranscriptomicsRegulatory mechanisms of TSG-6 (TNF-alfa-induced protein-6: Tnfip6)-deficient and wild-type synovial fibroblasts
BALB/c mice are susceptible to proteoglycan (PG) aggrecan-induced arthritis (PGIA), and the absence of TSG-6 further increases susceptibility and local inflammatory reactions, including neutrophil invasion into the joints. To gain insight into the mechanisms of TSG-6 action, synovial fibroblasts wer...
ORGANISM(S): Mus musculus 
2011-07-04 | E-GEOD-17160 | biostudies-arrayexpress
ProteomicsProteomic Analysis of the Interaction between Chicken Synovial Fibroblasts and Mycoplasma synoviae
Chicken synovial fibroblasts was infected without or with Mycoplasma synoviae for 48h
ORGANISM(S): Gallus Gallus 
2019-11-29 | PXD016513 |
TranscriptomicsRegulation of synovial DKK1 expression by local glucocorticoid metabolism in inflammatory arthritis
Inflammatory arthritis is associated with bone loss and fractures due to abnormal bone remodelling. Bone remodelling is 'uncoupled' with bone resorption increased and bone formation suppressed. These changes resemble those seen in patients treated with therapeutic glucocorticoids, and in both of the...
ORGANISM(S): Homo sapiens 
2012-04-24 | E-GEOD-37520 | biostudies-arrayexpress
TranscriptomicsDifferential gene expression in RA synovial biopsies from responders versus non-responders to adalimumab therapy
TNF antagonists are routinely used in severe rheumatoid arthritis (RA) patients who failed conventional DMARD therapy. According to large clinical trials, the three available drugs (adalimumab, infliximab and etanercept) display similar effects in terms of efficacy, tolerability and side effects. Th...
ORGANISM(S): Homo sapiens 
2009-04-15 | E-GEOD-15602 | biostudies-arrayexpress
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