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TranscriptomicsSystemic suppression of the rice shoot metabolism upon root rot nematode infection
Rice (Oryza sativa L.) is one of the most important staple foods in the world, feeding more than 50% of the human population. One of its most damaging pathogens, with major impact on rice yield, is the migratory root rot nematode Hirschmanniella oryzae. In comparison with the existing knowledge on t...
ORGANISM(S): Oryza sativa Japonica Group 
2015-05-18 | E-GEOD-57707 | biostudies-arrayexpress
ProteomicsNew insights into hypoxia-driven metabolic, anti-apoptotic and immune evasion strategies of primary human myeloma cells
Multiple Myeloma (MM) is an incurable plasma cell malignancy primarily localized within the bone marrow (BM). It develops from a premalignant stage, monoclonal gammopathy of undetermined significance (MGUS), often via an intermediate stage, smoldering MM (SMM). The mechanisms of MM progression have ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-10-17 | MSV000084470 | MassIVE
ProteomicsSystemic LRG1 expression in melanoma is associated with disease progression and recurrence
Treatment of late-stage melanoma patients with immune checkpoint blockade (ICB) is currently one of the most effective standard therapies. The response rates upon neoadjuvant ICB in stage III melanoma are higher as compared to stage IV disease. Given that successful ICB depends on systemic immune re...
ORGANISM(S): Homo sapiens (Human) 
2024-01-09 | PXD040399 | Pride
Lrg1 Melanoma Systemic immune suppression Serum Checkpoint inhibitor 
TranscriptomicsCXCR3+ Treg cells suppress Th1-immune responses through expression of the co-inhibitory receptors CD85k and Lag-3
CD4+Foxp3+ Treg cells are essential for maintaining self-tolerance and preventing excessive immune responses. In the context of Th1 immune responses, co-expression of the Th1 transcription factor T-bet with Foxp3 is essential for Treg cells to control Th1 responses. T-bet-dependent expression of CXC...
ORGANISM(S): Mus musculus 
2018-06-30 | E-MTAB-6156 | biostudies-arrayexpress
UnknownSystemic immune suppression predicts diminished Merkel cell carcinoma-specific survival independent of stage.
Not available
S-EPMC3570636 | biostudies-literature
TranscriptomicsA genomic storm in critically injured humans
Human survival from injury requires an appropriate inflammatory and immune response. We describe the circulating leukocyte transcriptome after severe trauma and show that the severe stress produce a global reprioritization affecting >80% of the cellular functions and pathways, a truly unexpected “ge...
ORGANISM(S): Homo sapiens 
2012-03-26 | E-GEOD-36809 | biostudies-arrayexpress
UnknownImmune suppression is associated with enhanced systemic inflammatory, endothelial and procoagulant responses in critically ill patients.
Not available
S-EPMC9312372 | biostudies-literature
UnknownReview article: novel methods for the treatment of non-alcoholic steatohepatitis - targeting the gut immune system to decrease the systemic inflammatory response without immune suppression.
Not available
S-EPMC5216447 | biostudies-literature
GenomicsLocal glycan engineering induces systemic antitumor immune reactions via antigen cross-presentation
Local glycan engineering induces systemic antitumor immune reactions via antigen cross-presentation
PRJNA1236389 | ENA
GenomicsBach2 represses effector programmes to stabilize Treg-mediated immune homeostasis
Through their functional diversification, CD4+ T cells play key roles in both driving and constraining immune-mediated pathology. Transcription factors are critical in the generation and maintenance of cellular diversity and negative regulators antagonistic to alternate fates often act in conjunctio...
ORGANISM(S): Mus musculus 
2013-06-27 | E-GEOD-45975 | biostudies-arrayexpress
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