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ModelsSlaviero2021 - E. coli anaerobic central carbon and energy metabolism_Version1
This model describes the central carbon and energy metabolism of E. coli growing under anaerobic conditions. For complete information about the model see: 'Deciphering the physiological response of Escherichia coli under high ATP demand Simon Boecker, Giulia Slaviero, Thorben Schramm, Witold Szyman...
2022-02-13 | MODEL2202020001 | BioModels
ProteomicsCorrection of indels in the atpB gene by genetic recoding in the chloroplast of Oenothera and tobacco
Genetic recoding, a process that modifies genome templated protein sequence, plays an important role especially in the small genomes of viruses and bacteria. Chloroplasts have evolved from cyanobacterial ancestry and mainly retain the prokaryotic gene expression machinery. I-iota, a plastome mutant ...
ORGANISM(S): Oenothera elata 
2022-02-15 | PXD020246 | Pride
Srm Tabacco Proteomics Oenothera Targeted Chloroplast 
ProteomicsLamin A acetylation shapes nuclear architecture and safeguards genomic integrity
The nuclear lamina constitutes more than a structural scaffold for the nucleus and plays a crucial role in protection of genomic integrity. Here we report that the loss of the lysine acetyl-transferase (KAT) MOF leads to nuclear architecture defects during interphase including micronuclei formation....
ORGANISM(S): Mus musculus (Mouse) 
2019-08-16 | PXD008539 | Pride
Acetylation Mouse Qexactive Lc-msms 
ProteomicsArachidonic acid suppresses natural killer cell functions by interfering with multiple signal transduction pathways
High levels of the polyunsaturated fatty acid arachidonic acid (AA) in the ovarian carcinoma (OC) microenvironment are associated with short relapse-free survival. OC progression is also linked to impaired immunosurveillance, due in part to dysfunctional natural killer (NK) cells. In the present stu...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-02-20 | MSV000094127 | MassIVE
Proteomics3D genome organization during TGFB-induced transcription requires nuclear microRNA and G-quadruplexes
Studying the dynamics of three-dimensional (3D) chromatin structure is essential to the understanding of biological processes in the nucleus. Integrative analysis of multi-omics data in recent publications have provided comprehensive and multilevel insight into 3D genome organization emphasizing its...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2024-07-30 | MSV000095480 | MassIVE
ProteomicsEngineering a new-to-nature cascade for phosphate-dependent formate to formaldehyde conversion in vitro and in vivo
To realize a carbon-neutral bioeconomy, the concept of electrobiocatalysis has been developed, in which CO2 is first chemically reduced to formate and subsequently assimilated by enzymatic cascades or engineered microbes. A key step in the assimilation of formate is its reduction into formaldehyde, ...
ORGANISM(S): Escherichia Coli (ncbitaxon:562) 
2023-03-22 | MSV000091532 | MassIVE
ProteomicsEpigenetic silencing of tight junction protein CLDN10B in renal cancer including post-transplantation RCC and its endogenous reactivation by CRISPR results in cell growth suppression.
Background The kidney's tubular system, composed of nephrons and collecting ducts, relies on cellular planar polarity and tight junctions to maintain structure and function. Disruptions in this polarity contribute to diseases like cystic kidney disease and cancer. Tight junctions, such as those form...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-10-01 | MSV000095998 | MassIVE
ProteomicsExtracellular vesicles from pancreatic cancer cells activate mast cells which in turn promote tumor cell proliferation and establish a tumor-supportive microenvironment
Background and aim: Recent studies reveal a critical role of tumor cell-released extracellular vesicles (EVs) in pancreatic cancer progression. Driver genes directing EV function, the EV-recipient cells, as well as their cellular response to EV uptake remain, however, to be identified. To address th...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2023-12-06 | MSV000093583 | MassIVE
ProteomicsDefective Olfactomedin-2 connects adipocyte dysfunction to obesity
Olfactomedin-2 (OLFM2) is a pleiotropic glycoprotein emerging as a regulator of energy homeostasis. We here show the expression of OLFM2 to be adipocyte-specific and inversely associated with obesity. OLFM2 levels increase during adipocyte differentiation and are suppressed in inflamed adipocytes. F...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2025-06-24 | MSV000098300 | MassIVE
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