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ProteomicsPolypropylene mesh implantation for hernia repair triggers myeloid cell-dependent persistent inflammatory foreign body reaction
Polypropylene meshes that are commonly used for surgical groin hernia repair may trigger granulomatous foreign body reactions. Here, we show that asymptomatic patients display mesh-associated inflammatory granulomas long after surgery, which are dominated by monocyte-derived macrophages. In mice, su...
ORGANISM(S): Mus musculus (Mouse) 
2019-01-24 | PXD009944 | Pride
Mouse Inflammation Chemokine Granuloma Macrophages Monocytes Biomaterial 
TranscriptomicsHepatic acute phase proteins control innate immune responses during infection by promoting myeloid derived suppressor cell function
Acute phase proteins (APPs) are an evolutionarily conserved family of proteins produced mainly in the liver in response to infection and inflammation. Despite vast pro- and anti-inflammatory properties ascribed to individual APPs, their collective function during infections remains poorly defined. U...
ORGANISM(S): Mus musculus 
2010-06-08 | E-GEOD-22009 | biostudies-arrayexpress
TranscriptomicsTranslation control of TAK1 mRNA by hnRNP K modulates LPS-induced macrophage activation
Macrophage activation by bacterial lipopolysaccharides (LPS) is induced through Toll-like receptor 4 (TLR4). The synthesis and activity of TLR4 downstream signalling molecules modulates the expression of pro- and anti-inflammatory cytokines. To address the impact of post-transcriptional regulation o...
ORGANISM(S): Mus musculus 
2014-07-01 | E-GEOD-48463 | biostudies-arrayexpress
TranscriptomicsComparison of gene expression profiles between human and mouse monocyte subsets [mouse data]
Human and mouse blood each contain two monocyte subsets. Here, we investigated the extent of their similarity using a microarray approach. Approximately 300 genes in human and 550 genes in mouse were differentially expressed between subsets. More than 130 of these gene expression differences were co...
ORGANISM(S): Mus musculus 
2009-12-03 | E-GEOD-17256 | biostudies-arrayexpress
UnknownAcute liver injury following acetaminophen administration does not activate atrophic pathways in the mouse diaphragm.
Not available
S-EPMC7973759 | biostudies-literature
UnknownPolypropylene mesh implantation for hernia repair causes myeloid cell-driven persistent inflammation.
Not available
S-EPMC6413778 | biostudies-literature
UnknownmicroRNA 193a-5p Regulates Levels of Nucleolar- and Spindle-Associated Protein 1 to Suppress Hepatocarcinogenesis.
Not available
S-EPMC6279541 | biostudies-literature
UnknownRare HCV subtypes and retreatment outcomes in a cohort of European DAA-experienced patients.
Not available
S-EPMC11246049 | biostudies-literature
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