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ProteomicsActinomycin targets NPM1c-primed mitochondria in AML
Acute myeloid leukemia (AML) pathogenesis often involves a mutation in the NPM1 nucleolar chaperone, but the bases for its transforming properties and association with favorable outcome remain incompletely understood. Here we demonstrate that an oncogenic mutant form of NPM1 (NPM1c) hampers formatio...
ORGANISM(S): Homo sapiens (Human) 
2021-12-17 | PXD025507 | Pride
Pml Lfq Actinomycin d Mitochondria Npm1c Qexactive Senescence 
ProteomicsProteomic profiling of AML patient-derived xenografts across serial transplantation
This dataset contains mass spectrometry-based proteomic profiling of acute myeloid leukemia patient-derived xenograft samples collected across serial transplantation stages. The study aimed to characterize proteome remodeling associated with leukemia propagation and disease evolution in AML PDX mode...
ORGANISM(S): Homo sapiens (Human) 
2026-07-20 | PXD078079 | Pride
Acute myeloid leukemia  aml  patient-derived xenograft  pdx  serial transplantation  proteomics  mass spectrometry  leukemia stem cells 
GenomicsPhotobacterium phosphoreum ANT-2200
Photobacterium phosphoreum ANT-2200
PRJEB5262 | ENA
TranscriptomicsMutations in RAS pathway induce synthetic lethality of MEK inhibition with mitochondrial oxidative metabolism in acute myeloid leukemia
Bulk RNAseq of primary AML samples at diagnosis
ORGANISM(S): Homo sapiens 
2021-12-31 | E-MTAB-10048 | biostudies-arrayexpress
ProteomicsAntileukemic activity of the VPS34-IN1 inhibitor in acute myeloid leukemia
Acute myeloid leukemia (AML) is an aggressive disease with a poor prognosis. Vacuolar protein sorting 34 (VPS34) is a member of the phosphatidylinositol-3-kinase lipid kinase family that controls the canonical autophagy pathway and vesicular trafficking. Using a recently developed specific inhibitor...
ORGANISM(S): Homo sapiens (Human) 
2020-11-11 | PXD016839 | Pride
Vps34-in1 Autophagy L-asparaginase Vps34 Human molm-14 cells Orbitrap fusion Aml 
ProteomicsHuman acute myeloid leukemia (AML) cell line LFQ, comparison between doxycycline-inducible control shRNA and Pim2 shRNA
Acute myeloid leukemia (AML) with the FLT3 internal tandem duplication (FLT3-ITD AML) accounts for 20-30% of AML cases. This subtype usually responds poorly to conventional therapies including FLT3 tyrosine kinase inhibitors (TKIs) due to molecular bypass mechanisms. New therapeutic strategies are t...
ORGANISM(S): Homo sapiens (Human) 
2017-09-18 | PXD005880 | Pride
Aml Rna interference Pim2 Lfq 
UnknownThe E3 ubiquitin ligase MARCH5 promotes mitochondrial fusion and cell-cycle progression in acute myeloid leukemia.
Not available
S-EPMC11787479 | biostudies-literature
UnknownMicrobiome modulation, microbiome protein metabolism index, and growth performance of broilers supplemented with a precision biotic.
Not available
S-EPMC10166706 | biostudies-literature
UnknownThe characterisation of shellac resin by flow injection and liquid chromatography coupled with electrospray ionisation and mass spectrometry.
Not available
S-EPMC5665916 | biostudies-literature
UnknownA multispectral imaging approach integrated into the study of Late Antique textiles from Egypt.
Not available
S-EPMC6171845 | biostudies-literature
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