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MetabolomicsDecipher aging related skin microbiome and metabolites crosstalk from a chronologically matched cohort

Aging has shown close link to shifts in the skin microbiome in population cohort study. However, how variations in microbial communities relate to divergent skin aging within individuals of the same chronological ages remains unclear. In this study, we performed phenotypic, metabolomic and metage...

2025-01-03 | MTBLS11994 | MetaboLights
UnknownAnti-enteric efficacy and mode of action of tridecanoic acid methyl ester isolated from Monochoria hastata (L.) Solms leaf.
Not available
S-EPMC9151942 | biostudies-literature
MetabolomicsEpimedium-Derived Extracellular Vesicles Alleviate Cisplatin-induced Acute Kidney Injury: Integrated Multi-Omics Analysis and Molecular Simulations Reveal Flavonoid Interactions with PPARα
This study explores the protective effects and potential underlying mechanisms of Epimedium-derived extracellular vesicles (EpEVs) against cisplatin-induced acute kidney injury (CIAKI) in mice. EpEVs were isolated and purified via differential centrifugation combined with sucrose and iodixanol gradi...
2026-09-02 | MTBLS15534 | MetaboLights
MetabolomicsAdipocyte-specific Zeb1 confers breast cancer progression by triggering the tumor-associated adipose microenvironment remodeling_untargeted metabolites_Lipidomics

Upon penetrating the basement membrane, breast cancer cells directly interact with their surrounding adipose tissue, which forms a unique tumor-associated adipose microenvironment (TAME). However, the underlying mechanism involved in the regulation of lipid metabolic remodeling in the TAME remain...

2025-04-30 | MTBLS12289 | MetaboLights
ProteomicsGastrobodies are engineered antibody mimetics resilient to pepsin and hydrochloric acid
Protein-based targeting reagents, such as antibodies and non-antibody scaffold proteins, are rapidly inactivated in the upper gastrointestinal (GI) tract. Hydrochloric acid in gastric juice denatures proteins and activates pepsin, concentrations of which reach 1 mg/mL in the mammalian stomach. Here ...
ORGANISM(S): Escherichia coli 
2021-08-13 | PXD027071 | Pride
Sbti Protease Gastrobody 
UnknownEarly-stage dynamics of chloride ion-pumping rhodopsin revealed by a femtosecond X-ray laser.
Not available
S-EPMC8020794 | biostudies-literature
ProteomicsHNSCC-derived factors promote fibroblast invasion
MS-based phosphoproteomic analysis was performed to investigate rapid and specific changes in the phosphorylation status and kinase activation in CAFs upon treatment with HNSCC CM (from FaDu and HCA-LSC1 cells) or Kc CM. Comparisons of phosphorylation levels were conducted at two different time poin...
ORGANISM(S): Homo sapiens (Human) 
2025-07-21 | PXD035527 | Pride
Cancer-associated fibroblasts Stromal fibroblasts Head and neck cancer Invasion Phosphoproteomics 
MetabolomicsA KRAS-triggered lactylation cascade forms the basis of chemotherapy resistance in colorectal cancer

KRAS-mutant colorectal cancer (KRASmut CRC) exhibits metabolic plasticity and chemoresistance, but the underlying mechanisms remain incompletely understood. Here, we show in CRC cells and organoids that KRAS-driven lactate accumulation promotes MCT1 K224 lactylation, which stabilizes mitochondria...

2026-10-16 | MTBLS16031 | MetaboLights
ProteomicsAn increase in oxidative stress downstream of mTORC1 but not AKT causes a proliferative defect in cancer cells with acquired resistance to PI3K/mTOR inhibitors
Proteomics and phosphoproteomics analysis of MCF7 cells sensitive and resistant to the PI3K inhibitor GDC-0941. The analysis was done for parental and 3 resistant cell lines maintained in the presence or the absence of the drug. One of the resistant cell lines (G2) was also treated with vehicle or t...
ORGANISM(S): Homo sapiens (Human) 
2018-04-09 | PXD003594 | Pride
Human Phosphoproteomics Metabolism Ltq-orbitrap Tio2 Pi3k resistance Q-exactive plus 
ProteomicsGastrointestinal digestion of hazelnut allergens on molecular level: Elucidation of degradation kinetics and resistant immunoactive peptides using mass spectrometry
Allergy to hazelnut seeds ranks among the most prevalent food allergies in Europe. The aim of this study was to elucidate the gastrointestinal digestion of hazelnut allergens on molecular level. Hazelnut flour was digested in vitro following the Infogest consensus model. For six allergenic proteins,...
ORGANISM(S): Corylus avellana 
2017-07-11 | PXD006412 | Pride
Food allergy Hazelnut Digestion Allergen 
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