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MetabolomicsTargeting transcription factor pu.1 for improving neurologic outcomes after spinal cord injury

Background: After spinal cord injury (SCI), lipid metabolism dysregulation at the lesion site exacerbates secondary damage. The transcription factor pu.1 has been implicated as a negative regulator of multiple lipid metabolism-related genes and pathways. However, its role in post-SCI lipid metabo...

2024-08-08 | MTBLS10453 | MetaboLights
MetabolomicsTargeting phospholipase PLAG-15 promotes healthy aging in C. elegans via lysosomal-related genes
Complex lipid metabolism plays a crucial role in regulating aging. We recently discovered that the phospholipid bis(monoacylglycero)phosphate (BMP) increases in aged human muscles and many mouse tissues. The phospholipase PLA2G15 is reportedly involved in BMP synthesis, however, its specific role in...
2025-06-19 | MTBLS12324 | MetaboLights
GenomicsTumor-specific retargeting of an oncogenic transcription factor chimera results in dysregulation of chromatin and transcription
Using EWS-FLI and its parental transcription factor, FLI1, we created a unique experimental system to address questions regarding the genomic mechanisms by which chimeric transcription factors cause cancer. We found that in tumor cells, EWS-FLI targets regions of the genome distinct from FLI1, despi...
ORGANISM(S): Homo sapiens 
2011-11-09 | E-GEOD-31838 | biostudies-arrayexpress
MetabolomicsTargeting STK39 ameliorates cardiac remodeling by Improving Mitochondrial function through degradation of IFIT3

Pathological cardiac remodeling in response to sustained pressure overload is a pivotal process in the progression of heart failure (HF), yet the underlying molecular mechanisms remain incompletely understood, limiting therapeutic development. Here, we identify serine/threonine kinase 39 (STK39) ...

2026-09-28 | MTBLS15834 | MetaboLights
MetabolomicsTargeting the SREBP-dependent lipidomic reprogramming by virus infection for broad-spectrum therapeutic intervention
Viruses are obligate intracellular parasites that exploit the host metabolic machineries to meet their extraordinary biosynthetic demands. Integrative transcriptomic and lipidomic profiling confirmed that Middle East respiratory syndrome coronavirus (MERS-CoV) infection reprograms the host lipid met...
2018-11-26 | MTBLS762 | MetaboLights
ProteomicsA bacterial autotransporter impairs innate immune responses by targeting the transcription factor TFE3
Type I interferons (IFNs) are consequential cytokines in antibacterial defense. Whether and how bacterial pathogens inhibit innate immune receptor-driven type I IFN expression remains mostly unknown. By screening a library of enterohemorrhagic Escherichia coli (EHEC) mutants, we uncovered EhaF, an ...
ORGANISM(S): Mus musculus (Mouse) Escherichia coli 
2023-04-13 | PXD041070 | Pride
Autotransporter Transcription factor Immune response Tfe3 Escherichia coli 
TranscriptomicsTranscription profiling of thymocytes from Kruppel-like transcription factor (KLF)13 knock-out mice
Kruppel-like transcription factor (KLF)13, previously shown to regulate RANTES expression in vitro, is a member of the Kruppel- like family of transcription factors that controls many growth and developmental processes. To ascertain the function of KLF13 in vivo, Klf13-deficient mice were generated ...
ORGANISM(S): Mus musculus 
2007-05-11 | E-SMDB-4035 | biostudies-arrayexpress
TranscriptomicsNeuroD1 reprograms chromatin and transcription factor landscapes to induce the neuronal program
Cell fate specification relies on the action of critical transcription factors that become available at distinct stages of embryonic development. One such factor is NeuroD1, which is essential for eliciting the neuronal development program and possesses the ability to reprogram other cell types into...
ORGANISM(S): Mus musculus 
2015-11-02 | E-GEOD-65072 | biostudies-arrayexpress
GenomicsDifferential genomic targeting of the transcription factor TAL1 in alternate hematopoietic lineages
TAL1/SCL is a master regulator of hematopoiesis whose expression promotes opposite outcomes depending on the cell type - differentiation in the erythroid lineage or oncogenesis in the T-cell lineage. Here we used a combination of ChIP-sequencing and gene expression profiling to compare the function ...
ORGANISM(S): Homo sapiens 
2010-10-30 | E-GEOD-25000 | biostudies-arrayexpress
MetabolomicsTargeting lung microbiota with Lactobacillus aerosolization: a novel strategy to alleviate inflammation and enhance productivity in broilers

Background In large-scale poultry farming, broilers of the same breed, sharing a common genetic background and identical management conditions, nevertheless exhibit considerable individual variation in body weight. Multitudinous stressors can profoundly influence the host microbiota, thereby...

2025-06-14 | MTBLS12595 | MetaboLights
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