Sort   by:  
 Page size 
ProteomicsProperties of Alzheimer’s disease brain-derived tau aggregates define tau processing by human astrocytes
The templated misfolding of tau proteins accounts for tau pathology spread in Alzheimer’s disease (AD). Post-translational modifications, including phosphorylation at specific residues, are closely linked with tau seeding ability and clinical disease progression. This study investigates the role of ...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD056614 | Pride
Tau  alzheimer’s disease  astrocyte 
ProteomicsPRM and DDA Data for IR5 WIW and WIW Nanobodies
Journal Article: Structure-based design of nanobodies that inhibit seeding of Alzheimer's patient-extracted tau fibrils
ORGANISM(S): Synthetic Antibodies Nanobodies 
2023-06-16 | MSV000092197 | MassIVE
ProteomicsSeed structure and phosphorylation in the fuzzy coat impact tau seeding competency
Tau is a pathogenic protein in Alzheimer’s (AD) and other neurodegenerative diseases. The misfolding of tau into β-sheet rich elongated filaments is thought to be a key event in disease pathogenesis, followed by subsequent templated recruitment of monomeric tau into this pathogenic form. Cryo-electr...
ORGANISM(S): Homo sapiens (Human) 
2025-08-05 | PXD062343 | Pride
Tauopathy Seeding Phosphorylation Prion-like 4r 3r 
ProteomicsTau Profiling of Brain Extracellular Vesicles Reveals PHF6 Peptide as Core for Pathological Tau Seeding in Alzheimer's Disease
EVs are bilipid spheres known for their role in cellular communication through transport of proteins, lipids, RNA and more. In the brain, EVs are directly released in the interstitial fluid surrounding neural cells and hence entitled brain-derived EVs (BD-EVs). Human BD-EVs of AD patients contain se...
ORGANISM(S): Homo Sapiens 
2026-09-06 | PXD067593 | panorama
Genomics4R-Tau Seeding Activity Reveals Molecular Subtypes in Progressive Supranuclear Palsy
4R-Tau Seeding Activity Reveals Molecular Subtypes in Progressive Supranuclear Palsy
PRJNA1289105 | ENA
ProteomicsQuantitative PTM Maps of Human Pathologic Tau Identify Patient Heterogeneity and Define Critical Steps in Alzheimer’s Disease Progression - MC1-isolated Tau
To elucidate the role of Tau isoforms and PTM stoichiometry in Alzheimer’s disease (AD), we generated a high resolution quantitative proteomic map of 88 PTMs on multiple isoforms of Tau isolated from the post-mortem human tissue from 49 AD and 42 control subjects. While Tau PTM maps reveal heterogen...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-11-18 | MSV000088408 | MassIVE
ProteomicsQuantitative PTM Maps of Human Pathologic Tau Identify Patient Heterogeneity and Define Critical Steps in Alzheimer’s Disease Progression - high/low molecular weight tau
To elucidate the role of Tau isoforms and PTM stoichiometry in Alzheimer’s disease (AD), we generated a high resolution quantitative proteomic map of 88 PTMs on multiple isoforms of Tau isolated from the post-mortem human tissue from 49 AD and 42 control subjects. While Tau PTM maps reveal heterogen...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-11-17 | MSV000088405 | MassIVE
ProteomicsSerine-65 phosphorylated ubiquitin associates with soluble Tau and seeding activity in Alzheimer’s disease
Tau propagation is a key driver of Alzheimer’s disease (AD), yet selective markers of seeding-competent tau remain elusive. Ubiquitin phosphorylated at Serine-65 (pS65-Ub) is a PINK1-derived stress signal that accumulates in AD with elevated tau pathology, but its functional relationship to tau seed...
ORGANISM(S): Homo sapiens (Human) 
2026-09-02 | PXD079144 | Pride
Tau seeding Phosphorylated ubiquitin Alzheimer’s disease Ps65-ub 
ProteomicsQuantitative PTM Maps of Human Pathologic Tau Identify Patient Heterogeneity and Define Critical Steps in Alzheimer’s Disease Progression - frontal gyrus
To elucidate the role of Tau isoforms and PTM stoichiometry in Alzheimer’s disease (AD), we generated a high resolution quantitative proteomic map of 88 PTMs on multiple isoforms of Tau isolated from the post-mortem human tissue from 49 AD and 42 control subjects. While Tau PTM maps reveal heterogen...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-11-18 | MSV000088407 | MassIVE
ProteomicsQuantitative PTM Maps of Human Pathologic Tau Identify Patient Heterogeneity and Define Critical Steps in Alzheimer’s Disease Progression - angular gyrus
To elucidate the role of Tau isoforms and PTM stoichiometry in Alzheimer’s disease (AD), we generated a high resolution quantitative proteomic map of 88 PTMs on multiple isoforms of Tau isolated from the post-mortem human tissue from 49 AD and 42 control subjects. While Tau PTM maps reveal heterogen...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-11-18 | MSV000088406 | MassIVE
Sort   by:  
 Page size