We report the identification of dopaminechrome tautomerase (DPT) that biosynthesizes 5,6-dihydroxyindole from dopaminechrome in Drosophila. We show that this enzyme is encoded by the yellow-h gene.
One of the major primary features of the neurocutaneous genetic disorder Neurofibromatosis type 1 are the hyperpigmentary café-au-lait macules where dysregulation of melanocyte development, proliferation and differentiation is considered to play a key etiopathogenic role. To gain better insight in t...
