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TranscriptomicsTranscription profiling of human Hepatitis C patients - responders and non-responders to antiviral therapies peg interferon and ribavirin against hepatitis C
Time series of gene expression arrays before and during treatment of Hepatitis C; days 0, 1, 2, 7, 14 and 28 for 69 participants (IDs 1 through 69 are used). Treating chronic hepatitis C using peginterferon alpha and ribavirin leads to sustained clearance of virus and clinical improvement in approxi...
ORGANISM(S): Homo sapiens 
2008-06-16 | E-GEOD-7123 | biostudies-arrayexpress
Proteomicsc-Abl Dependent Tyrosine Phosphorylation of theCo-chaperone Aha1 Regulates Interaction with Hsp90
The ability of Heat Shock Protein 90 (Hsp90) to hydrolyze ATP is essential for its chaperone function. The co-chaperone Aha1 stimulates Hsp90 ATPase activity tailoring the chaperone function to specific “client” proteins. The intracellular signaling mechanisms directly regulating Aha1 association wi...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-28 | MSV000080713 | MassIVE
ProteomicsC. elegans provide "milk" for their young
The nematode Caenorhabditis elegans exhibits rapid senescence that is promoted by the insulin/IGF-1 signaling (IIS) pathway via regulated processes that are poorly understood. IIS also promotes production of yolk for egg provisioning, which in post-reproductive animals continues, supported by destru...
ORGANISM(S): Caenorhabditis elegans 
2022-02-17 | PXD025472 | Pride
C. elegans Ageing Reproductive death Milk Yolk Semelparity 
ProteomicsCENP-C-targeted PLK-1 regulates kinetochore function in C. elegans embryos
This project focused on the identification of phosphorylation sites on the C. elegans inner kinetochore protein CENP-C and the outer kinetochore complex MIS12. Phosphorylation was carried out in vitro using recombinant proteins. CENP-C was phosphorylated with Cdk1, PLK-1 or both; MIS12 complex compo...
ORGANISM(S): Caenorhabditis elegans 
2024-11-28 | PXD058379 | Pride
Plk-1 Inner kinetochore Cenp-c Mis12 complex. 
TranscriptomicsTranscription profiling of human hepatitis PBMC C patients treated with Peg-interferon alfa-2b plus ribavirin during the first 10 weeks of treatment
Study of PBMC gene expression during the first 10 weeks of therapy with Pegylated-interferon-alfa2b (PegIntronTM) and ribavirin (administered by weight) in HCV patients. This study compared the kinetics of gene expression during the first 10 weeks of therapy with Pegylated-interferon-alfa2b (PegIntr...
ORGANISM(S): Homo sapiens 
2009-05-03 | E-GEOD-11342 | biostudies-arrayexpress
TranscriptomicsThe blood transcriptional signature of chronic HCV [Affymetrix data]
This study characterizes the effects of chronic Hepatitis C virus (HCV) infection on gene expression by analyzing blood samples from 10 treatment-naive HCV patients and 6 healthy volunteers. Differential expression analysis of microarray data from peripheral blood mononuclear cells (PBMCs) identifie...
ORGANISM(S): Homo sapiens 
2012-10-22 | E-GEOD-40184 | biostudies-arrayexpress
UnknownPaired Electrosynthesis at Interdigitated Microband Array Electrodes without Intentionally Added Electrolyte: C-C Coupling of Dicyanobenzenes with Methanol.
Not available
S-EPMC11833768 | biostudies-literature
TranscriptomicsRNA-seq of whole animal tissue and AWA olfactory neurons isolated by FACS from control and post-dauer L4 larval stage C. elegans
Developmental experiences play critical roles in shaping adult physiology and behavior. We and others previously showed that adult C. elegans which transiently experienced dauer arrest during development (PD: post-dauer) exhibit distinct gene expression profiles as compared to control adults which b...
ORGANISM(S): Caenorhabditis elegans 
2022-09-07 | E-MTAB-11823 | biostudies-arrayexpress
UnknownEffect of multifunctional cationic polymer coatings on mitigation of broad microbial pathogens.
Not available
S-EPMC11370243 | biostudies-literature
TranscriptomicsL-Glutamine metabolism and its regulation in C. glutamicum
Corynebacterium glutamicum, a gram-positive soil bacterium used for the industrial production of amino acids such as L-glutamate and L-lysine, is able to use a number of different nitrogen sources, such as ammonium, urea, or creatinine. In this communication, we show that L-glutamine serves as an ex...
ORGANISM(S): Corynebacterium glutamicum ATCC 13032 
2010-10-05 | E-GEOD-19779 | biostudies-arrayexpress
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