Sort   by:  
 Page size 
MetabolomicsTemporal characterization of serum metabolite signatures in lung cancer patients undergoing treatment
Lung cancer causes more deaths in men and women than any other cancer related disease. Currently, few effective strategies exist to predict how patients will respond to treatment. We evaluated the serum metabolomic profiles of 25 lung cancer patients undergoing chemotherapy ± radiation to evaluate t...
2017-01-19 | MTBLS200 | MetaboLights
MetabolomicsOrganotypic microfluidic breast cancer model reveals starvation-induced spatial-temporal metabolic adaptations
BACKGROUND: Ductal carcinoma in situ (DCIS) is the earliest stage of breast cancer. During DCIS, tumor cells remain inside the mammary duct, growing under a microenvironment characterized by hypoxia, nutrient starvation, and waste product accumulation; this harsh microenvironment promotes genomic in...
2019-02-08 | MTBLS669 | MetaboLights
MetabolomicsNon-canonical Metabolic and Molecular Effects of Calorie Restriction Are Revealed by Varying Temporal Conditions

Calorie restriction (CR) extends lifespan and healthspan in diverse species. However, comparing ad libitum (AL) and CR-fed mice is challenging due to their significantly different feeding patterns. CR-fed mice consume their daily meal in approximately 2 hours, subjecting themselves to a prol...

2025-07-07 | MTBLS10795 | MetaboLights
MetabolomicsDiurnal Dynamics Shape Plant Defense Responses: Temporal Variations in Disease Progression and Metabolic Reprogramming in Brassica oleracea
Plants synchronize their immune responses with the circadian cycle, yet the impact of diurnal timing on disease resistance remains poorly understood in crop species. In this study, we investigated how diurnal variation modulates defense responses in Brassica oleracea against Xanthomonas campestris p...
2025-08-22 | MTBLS7854 | MetaboLights
MetabolomicsUnraveling the metabolic response of Brassica oleracea exposed to Xanthomonas campestris pv. campestris

BACKGROUND: Brassica crops together with cereals represent the basis of world supplies. Due to their importance, the production losses caused by Xanthomonas campestris pv. campestris (Xcc) infection represent a high economic impact. Understanding molecular and biochemical mechani...

2021-10-06 | MTBLS460 | MetaboLights
Metabolomics1H HR-MAS NMR Based Metabolic Profiling of Cells in Response to Treatment with a Hexacationic Ruthenium Metallaprism as Potential Anticancer Drug
1H high resolution magic angle spinning (HR-MAS) NMR spectroscopy was applied in combination with multivariate statistical analyses to study the metabolic response of whole cells to the treatment with a hexacationic ruthenium metallaprism [1]6+ as potential anticancer drug. Human ovarian cancer cell...
2015-01-16 | MTBLS156 | MetaboLights
MetabolomicsSexual dimorphism in the fetal cardiac response to maternal nutrient restriction
Poor maternal nutrition causes intrauterine growth restriction (IUGR); however, its effects on fetal cardiac development are unclear. We have developed a baboon model of moderate maternal undernutrition, leading to IUGR. We hypothesized that the IUGR affects fetal cardiac structure and metabolism. S...
2018-04-30 | MTBLS426 | MetaboLights
MetabolomicsHigh metabolic variation for seaweeds in response to environmental changes: a case study of the brown algae Lobophora in coral reefs
In the marine environment, macroalgae face changing environmental conditions and some species are known for their high capacity to adapt to the new factors of their ecological niche. Some macroalgal metabolites play diverse ecological functions and belong to the adaptive traits of such species. Beca...
2019-09-02 | MTBLS707 | MetaboLights
ProteomicsStable and temporal interactomes of CBL and CBLB
CBL family proteins have been widely reported as negative regulators of various signal pathways, which determines the amplitude and duration of signaling response through mediating the ubiquitination and degradation of activated receptors. CBL and CBLB share high degrees of structural similarities, ...
ORGANISM(S): Homo sapiens (Human) 
2026-07-14 | PXD025250 | Pride
Cbl Cblb Signal transduction Dynamic protein complexes Ap-ms 
ProteomicsBacillus subtilis under Curcumin treatment LC-MS/MS
Comprehensive Analysis of Temporal Alterations in Cellular Proteome of Bacillus subtilis under Curcumin Treatment
ORGANISM(S): Bacillus subtilis subsp. subtilis str. 168 
2019-11-20 | PXD000644 | Pride
Bacillus Curcumin Lc-ms/ms 
Sort   by:  
 Page size