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ProteomicsProteomic changes in the hypothalamus after treatment with GLP-1RA, Tesaglitazar, or GLP-1RA/Tesaglitazar (GLP-1RA mediated Tesaglitazar delivery)
The peroxisome proliferator-activated receptors alpha and gamma (PPAR𝛼/𝛾) play important roles in the regulation of energy, lipid and glucose metabolism. Drugs targeting these proteins such as Fibrates and TZDs have both shown beneficial cardiovascular effects in clinical trials, which together wi...
ORGANISM(S): Mus musculus (Mouse) 
2022-10-07 | PXD033653 | Pride
Tesaglitazar Glp-1ra Glp-1 Mouse Hypothalamus Targeted delivery 
TranscriptomicsExpression data from liver, PFC and amygdala of mice treated with PPAR agonists
Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that act as ligand-activated transcription factors. Although prescribed for dyslipidemia and type-II diabetes, PPAR agonists have demonstrated therapeutic properties for several brain disorders, including alcohol depen...
ORGANISM(S): Mus musculus 
2015-04-14 | E-GEOD-67796 | biostudies-arrayexpress
UnknownGLP-1-mediated delivery of tesaglitazar improves obesity and glucose metabolism in male mice.
Not available
S-EPMC9398908 | biostudies-literature
UnknownPPAR Agonists: II. Fenofibrate and Tesaglitazar Alter Behaviors Related to Voluntary Alcohol Consumption.
Not available
S-EPMC4775356 | biostudies-literature
UnknownIn vivo liposomal delivery of PPARα/γ dual agonist tesaglitazar in a model of obesity enriches macrophage targeting and limits liver and kidney drug effects.
Not available
S-EPMC6929996 | biostudies-literature
ProteomicsAntidiabetic PPARγ Antidiabetic PPARγ agonist Pioglitazone inhibits cell proliferation and induces metabolic reprogramming in prostate cancer cellsonist Pioglitazone inhibits cell proliferation and induces metabolic reprogramming in prostate cancer cells
Background: Prostate cancer (PCa) and Type 2 diabetes (T2D) are two major health risks that often occur concurrently in men. Studies predict that diabetic PCa patients have a reduced risk of PCa progression, while other studies show contradicting data. This impedes unraveling the connection between ...
ORGANISM(S): Homo sapiens (Human) 
2025-08-11 | PXD060526 | Pride
Prostate cancer cells  ppar agonists  proteome and metabolic reprogramming 
TranscriptomicsExpression data from liver, PFC and amygdala of mice treated with PPAR agonists
Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that act as ligand-activated transcription factors. Although prescribed for dyslipidemia and type-II diabetes, PPAR agonists have demonstrated therapeutic properties for several brain disorders, including alcohol depen...
ORGANISM(S): Mus musculus 
2015-04-14 | GSE67796 | GEO
UnknownNPY1R-targeted peptide-mediated delivery of a dual PPARα/γ agonist to adipocytes enhances adipogenesis and prevents diabetes progression.
Not available
S-EPMC6931124 | biostudies-literature
UnknownPPAR Agonists: I. Role of Receptor Subunits in Alcohol Consumption in Male and Female Mice.
Not available
S-EPMC4775296 | biostudies-literature
TranscriptomicsComparative Transcriptional Network Modeling of Three PPAR-α/γ Co-agonists Reveals Distinct Metabolic Gene Signatures in Primary Human Hepatocytes
Aims: To compare the molecular and biologic signatures of a balanced dual peroxisome proliferator-activated receptor-α/γ (PPAR-α/γ) agonist, aleglitazar, with tesaglitazar (a dual PPAR-α/γ agonist) or combination of pioglitazone (PPAR-γ agonist)/fenofibric acid (PPAR-α agonist) in human hepatocytes....
ORGANISM(S): Homo sapiens 
2011-10-22 | GSE33152 | GEO
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