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ProteomicsProteomic changes in the hypothalamus after treatment with GLP-1RA, Tesaglitazar, or GLP-1RA/Tesaglitazar (GLP-1RA mediated Tesaglitazar delivery)
The peroxisome proliferator-activated receptors alpha and gamma (PPAR𝛼/𝛾) play important roles in the regulation of energy, lipid and glucose metabolism. Drugs targeting these proteins such as Fibrates and TZDs have both shown beneficial cardiovascular effects in clinical trials, which together wi...
ORGANISM(S): Mus musculus (Mouse) 
2022-10-07 | PXD033653 | Pride
Tesaglitazar Glp-1ra Glp-1 Mouse Hypothalamus Targeted delivery 
UnknownGLP-1RA Use and Thyroid Cancer Risk.
Not available
S-EPMC11907303 | biostudies-literature
UnknownCardiovascular outcomes of empagliflozin-GLP-1RA combination therapy in type 2 diabetes: EMPRISE study.
Not available
S-EPMC13644152 | biostudies-literature
UnknownA FIDELITY Analysis on Finerenone With SGLT-2i and GLP-1RA in CKD.
Not available
S-EPMC12860910 | biostudies-literature
TranscriptomicsMicroarray was used to detect the expression of lncRNAs and mRNAs in INS-1 cells treated with GLP-1RA Geniposide for 24 hours.
Studies have shown that long noncoding RNAs (lncRNAs) can be widely involved in various physiological and pathological processes. In recent years, there have been many studies on GLP-1 receptor agonists (GLP-1RA) regulating islet β cells function and mass of type 2 diabetes (T2DM) patients. However,...
ORGANISM(S): Rattus norvegicus 
2020-10-06 | GSE138744 | GEO
UnknownGLP-1RA in JBMMSCs promoted osteogenic differentiation via modulating CREB and BRD4 signaling mediated proliferation and stemness.
Not available
S-EPMC12630770 | biostudies-literature
GenomicsMicroarray was used to detect the expression of lncRNAs and mRNAs in INS-1 cells treated with GLP-1RA Geniposide for 24 hours.
Microarray was used to detect the expression of lncRNAs and mRNAs in INS-1 cells treated with GLP-1RA Geniposide for 24 hours.
PRJNA577059 | ENA
ProteomicsGLP-1RA Ameliorates Polycystic Ovary Syndrome via Hypothalamic RASA1/AKT: A Novel pathway Linking Hyperandrogenism to GnRH Dysregulation
Polycystic ovary syndrome (PCOS) is characterized by hyperandrogenemia and hypothalamic-pituitary-gonadal (HPG) axis dysregulation involving gonadotropin-releasing hormone (GnRH) hyperactivity. While glucagon-like peptide-1 receptor agonists (GLP-1RAs) show therapeutic promise in PCOS, their central...
ORGANISM(S): Rattus Norvegicus 
PXD064291 |
UnknownGLP-1RA-induced delays in gastrointestinal motility: Predicted effects on coadministered drug absorption by PBPK analysis.
Not available
S-EPMC11998891 | biostudies-literature
UnknownImpact of GLP-1RA on the Risk of Adverse Liver Outcomes Among Patients With Alcohol-Associated Liver Disease and Type 2 Diabetes.
Not available
S-EPMC11892336 | biostudies-literature
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