Testicular aging

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Unknown (154)
Genomics (37)
Transcriptomics (23)
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Organisms

Mus musculus (16)
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mouse gut metagenome (1)

Repository

ENA (33)
geo (20)
biostudies-arrayexpress (7)
pride (6)
MetaboLights (1)

Tissue

Testis (4)
Peritubular myoid cell (2)
Cell culture (1)

Disease

Disease free (1)

Technology Type

Mass Spectrometry (6)
Bottom-up proteomics (3)
Shotgun proteomics (3)
Mass spectrometry (1)
Data-dependent acquisition (1)

Instrument Platform

Illumina HiSeq 2500 (2)
Liquid Chromatography MS - negative - hilic (1)
Liquid Chromatography MS - positive - hilic (1)

Publication Date

2026 (10)
2025 (6)
2024 (5)
2021 (4)
2014 (3)
2022 (2)
2013 (1)
2012 (1)
2023 (1)
2020 (1)

CHEBI ID

CHEBI:132640 (1)
CHEBI:53750 (1)
CHEBI:166414 (1)
CHEBI:166124 (1)
CHEBI:166046 (1)
CHEBI:164903 (1)
CHEBI:164724 (1)
CHEBI:164538 (1)
CHEBI:164476 (1)
CHEBI:164457 (1)
CHEBI:164265 (1)
CHEBI:163670 (1)
CHEBI:65326 (1)
CHEBI:184105 (1)
CHEBI:181765 (1)
CHEBI:163120 (1)
CHEBI:163000 (1)
CHEBI:47458 (1)
CHEBI:184099 (1)
CHEBI:184095 (1)
CHEBI:162100 (1)
CHEBI:161829 (1)
CHEBI:184084 (1)
CHEBI:143141 (1)
CHEBI:31912 (1)
CHEBI:93748 (1)
CHEBI:182616 (1)
CHEBI:131843 (1)
CHEBI:161145 (1)
CHEBI:161048 (1)

Metabolite Name

Trp-Tyr-Lys (1)
Thr-Arg-Lys (1)
Ser-Cys-Lys (1)
Ptaeroxylin (1)
Prostaglandin b3 (1)
Piperonyl alcohol (1)
N-arachidonoyl-3-hydroxy-gamma-aminobutyric acid (1)
N-(3-hydroxy-2-methylbenzoyl)-l-valyl-n-[(1s,2e)-4-ethoxy-1-(2-methylpropyl)-4-oxo-2-butenyl]-l-serinamide (1)
Met-Ser-Arg (1)
Met-Gly-Lys (1)
Leu-Phe-Arg (1)
Leu-Ile-Lys (1)
Disialyllacto-n-tetraose (1)
Dioxydemeton-s-methyl (1)
Dihydro-8-deoxy-lactucin (1)
Cys-Thr-Lys (1)
Chrysosplenol d (1)
Beta-d-glucopyranosiduronic acid, 5-[3-(1-naphthalenylcarbonyl)-1h-indol-1-yl]pentyl (1)
Beta-alanine, n-[2-(2-pyridinyl)-6-(1,2,4,5-tetrahydro-3h-3-benzazepin-3-yl)-4-pyrimidinyl]- (1)
Bacoside a3 (1)
Ala-Lys-Arg (1)
7-aminoactinomycin d (1)
5z,8z,14z-eicosatrienoic acid (1)
5-heptenoic acid, 7-[(1r,2r,3s,5s)-2-[(1e,3r)-3-(2,3-dihydro-1h-inden-2-yl)-3-hydroxy-1-propen-1-yl]-3-fluoro-5-hydroxycyclopentyl]-, methyl ester, (5z)- (1)
5beta-androsterone (1)
5,3'-dihydroxy-4',5'-dimethoxy-6,7-methylenedioxyisoflavone (1)
4h-1-benzopyran-4-one, 2-(2-amino-3-methoxyphenyl)- (1)
3alpha-mannobiose (1)
2-thiophenecarboxamide, 5-(5,6-dimethoxy-1h-benzimidazol-1-yl)-3-[[4-(methylsulfonyl)phenyl]methoxy]- (1)
2-acetamido-2-deoxy-3-o-(alpha-l-fucopyranosyl)-d-glucopyranose (1)

First Public Date

2026 (13)
2025 (6)
2024 (5)
2021 (5)
2023 (1)
2022 (1)
2020 (1)
2014 (1)

Study type

Transcription profiling by array (4)
RNA-seq of coding RNA from single cells (2)
ChIP-seq (1)

Release Date

2024 (24)
2020 (22)
2025 (20)
2023 (17)
2021 (17)
2022 (13)
2019 (9)
2017 (8)
2014 (5)
2026 (4)
2018 (4)
2016 (4)
2013 (3)
2015 (3)
2011 (3)
2012 (2)
2010 (2)
2007 (1)

Lab affiliation

Department of Andrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, China (1)
Gene Center Laboratory for Functional Genome Analysis Feodor-Lynen-Str. 25 D-81377 München (1)
III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (1)
Institute of Reproductive Medicine, Medical School, Nantong University, Nantong 226001, China (1)
Laboratory for Functional Genome Analysis LAFUGA, Gene Center, LMU München, Feodor-Lynen-Strasse 25, 81377 Munich, Germany (1)
Laboratory for Functional Genome Analysis LAFUGA, Gene Center, LMU München, München, Germany (1)

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Aging of the human testis and associated cellular changes are difficult to assess, thus we used a translational non-human primate model to get insights into underlying biochemical processes. Using proteomics we analyzed testicular tissue of six young (age 2 to 3) and four old (age 10 to 12) C. jacch...

ORGANISM(S): Callithrix jacchus

2021-06-21 | PXD024844 | Pride

Mass spectrometry analysis of the testicular interstitial fluid exosome

Aging is characterized by a chronic, persistent and low-grade inflammatory response, and mitochondrial dysfunction plays an important role in inflammation in aging testes. Proteomic sequencing analysis of testicular mesenchymal exosomes showed differential expression profiles in young and aging test...

ORGANISM(S): Mus musculus (Mouse)

2024-02-16 | PXD049210 | Pride

Mouse Testis Exosome

Integrity of hypothalamic-pituitary-testicular axis in exceptional longevity.

Not available

S-EPMC9381897 | biostudies-literature

Impaired ketogenesis in Leydig Cells drives testicular aging

Testicular aging commonly leads to testosterone deficiency and impaired spermatogenesis, yet the underlying mechanisms remain elusive. Here, a comprehensive analysis of senescence landscapes in mice testes during aging revealed that the Leydig cells (LCs) are particularly vulnerable to aging process...

ORGANISM(S): Mus musculus

2025-03-27 | GSE287203 | GEO

Single-cell transcriptomics identifies senescence-associated secretory phenotype (SASP) features of testicular aging in human.

Not available

S-EPMC10929807 | biostudies-literature

Lipid Droplet-Driven Ribosome Collisions Trigger ZAKα-p38 Signaling to Accelerate Testicular Aging.

Not available

S-EPMC12759184 | biostudies-literature

Transcriptome Analysis of Testicular Aging in Mice.

Not available

S-EPMC8616291 | biostudies-literature

Long-term exposure to polystyrene microplastics triggers premature testicular aging.