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Aging is characterized by a chronic, persistent and low-grade inflammatory response, and mitochondrial dysfunction plays an important role in inflammation in aging testes. Proteomic sequencing analysis of testicular mesenchymal exosomes showed differential expression profiles in young and aging test...
ORGANISM(S): Mus musculus (Mouse) 
2024-02-16 | PXD049210 | Pride
Sperm develop in the seminiferous tubules of the testis from puberty, sequestered inside the blood-testis barrier to prevent their recognition as “non-self” by the immune system. It is widely assumed that proteins expressed specifically in sperm do not have direct access to the circulation or the im...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2021-04-01 | PXD014333 | Pride
Methoxyacetic acid (MAA) is the active metabolite of the widely used industrial chemical ethylene glycol monomethyl ether, an established testicular toxicant. MAA induces the degradation of testicular germ cells in association with changes in gene expression in both germ cells and Sertoli cells of ...
ORGANISM(S): Mus musculus 
Abstract: Testicular cancers in young adult men derive from an inborn precursor lesion, called carcinoma in situ (CIS) of the testis. CIS cells are believed to arise from primordial germ cells or gonocytes that fail to differentiate into the male germ cell lineage, and show a remarkable resemblance ...
ORGANISM(S): Homo sapiens 
TSLC1/IGSF4, an immunoglobulin superfamily molecule, is predominantly expressed in the brain, lung, and testis and plays important roles in epithelial cell adhesion, cancer invasion, and synapse formation. We generated Tslc1/Igsf4-deficient mice by disrupting exon 1 of the gene and found that Tslc1...
ORGANISM(S): Mus musculus 
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