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ProteomicsTetraspanin 4 stabilizes membrane swellings and facilitates their maturation into migrasomes
Migrasomes are newly discovered cell organelles forming by local swelling of retraction fibers. The migrasome formation critically depends on tetraspanin proteins present in the retraction fiber membranes and is modulated by the membrane tension and bending rigidity. It remained unknown how and in w...
ORGANISM(S): Homo sapiens (Human) 
2023-01-29 | PXD039664 | Pride
Migrasome Tetraspanin 4 
TranscriptomicsDifferentiated vs. undifferentiated promyelocytic cell lines (HL-60 and KG-1) and Neutrophiles
We identify the tetraspanin CD82 as the recognition site for xenogeneic endothelial cells independently of Gala1,3-gal structures. We demonstrate that in contrast to undifferentiated cells, differentiated promyelocytic cell lines (HL-60, THP-1 and KG-1) are capable of recognizing xenogeneic porcine...
ORGANISM(S): Homo sapiens 
2013-08-05 | E-GEOD-43211 | biostudies-arrayexpress
TranscriptomicsTetraspanin CD63 acts as a pro-metastatic factor via β-catenin stabilization
The tetraspanin CD63 is implicated in pro-metastatic signaling pathways, but so far, it is unclear how CD63 levels affect the tumor cell phenotype. Here, we investigated the effect of CD63 modulation in different metastatic tumor cell lines. In vitro, knock down of CD63 induced a more epithelial-lik...
ORGANISM(S): Homo sapiens 
2015-01-23 | E-GEOD-61957 | biostudies-arrayexpress
UnknownTetraspanin 4 stabilizes membrane swellings and facilitates their maturation into migrasomes.
Not available
S-EPMC9950420 | biostudies-literature
ProteomicsTetraspanin-6 antagonizes the release of exosomes by stimulating the lysosomal degradation of syntenin and syndecan-4
Exosomes, extracellular vesicles (EV) of endosomal origin, emerge as master regulators of cell-to-cell signaling in physiology and various systemic diseases. Exosomes are highly enriched in tetraspanins (TSPN) and syndecans (SDC), the latter occurring mainly in proteolytically-cleaved form, as membr...
ORGANISM(S): Homo sapiens (Human) 
2020-02-12 | PXD014559 | Pride
Human Lc-msms Exosomes Tetraspanin Gfp-trap Syntenin 
UnknownTransmembrane proteins tetraspanin 4 and CD9 sense membrane curvature.
Not available
S-EPMC9618112 | biostudies-literature
TranscriptomicsTetraspanin TSPAN12 regulates tumor growth and metastasis and inhibits b-catenin degedation
Ablation of tetraspanin protein TSPAN12 from human MDA-MB-231 cells resulted in a major decrease in primary tumor xenograft growth, accompanied by a significant increase in tumor apoptosis. Furthermore, TSPAN12 removal markedly increased metastasis to mouse lungs, due to enhanced tumor-endothelial i...
ORGANISM(S): Homo sapiens 
2012-10-29 | E-GEOD-41892 | biostudies-arrayexpress
UnknownThe Impact of the CD9 Tetraspanin on Lentivirus Infectivity and Exosome Secretion.
Not available
S-EPMC5835022 | biostudies-literature
GenomicsTetraspanin CD151 protects against pulmonary fibrosis by maintaining epithelial integrity
Tetraspanin CD151 protects against pulmonary fibrosis by maintaining epithelial integrity
PRJNA668118 | ENA
UnknownStructural basis for regulation of Frizzled-4 signaling by the co-receptor Tetraspanin-12.
Not available
S-EPMC12485846 | biostudies-literature
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