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ProteomicsHMGB1 interactome in prostate and ovarian cancer cells
This study reports the interactome of HMGB1 in prostate and ovarian cancer cells, which includes a variety of proteins involved in diverse cellular processes. Subcellular fractionation is used to map the distribution of interacting proteins. In the nucleus, HMGB1 interacts directly with NuRD complex...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD026258 | Pride
Septin Thoc complex Prostate cancer Ovarian cancer Ribosome biogenesis Hmgb1 Skov-1 Nurd complex Rab11 Pc3 
UnknownHMGB1 Protein Interactions in Prostate and Ovary Cancer Models Reveal Links to RNA Processing and Ribosome Biogenesis through NuRD, THOC and Septin Complexes.
Not available
S-EPMC8466577 | biostudies-literature
UnknownThe THO complex counteracts TERRA R-loop-mediated telomere fragility in telomerase+ cells and telomeric recombination in ALT+ cells.
Not available
S-EPMC10359610 | biostudies-literature
UnknownThe THO Complex Coordinates Transcripts for Synapse Development and Dopamine Neuron Survival.
Not available
S-EPMC6542560 | biostudies-literature
OtherYTHDC1 cooperates with the THO complex to prevent RNA damage-induced DNA breaks
Certain environmental toxins are nucleic acid damaging agents, as are many chemotherapeutics used for cancer therapy. These agents induce various adducts in DNA as well as RNA. Indeed, most of the nucleic acid adducts (>90%) formed due to these chemicals, such as alkylating agents, occur in RNA. How...
ORGANISM(S): Homo sapiens 
2024-12-03 | GSE283317 | GEO
GenomicsRNA helicase Ighmbp2 regulates THO complex to ensure cellular mRNA homeostasis
RNA helicase Ighmbp2 regulates THO complex to ensure cellular mRNA homeostasis
PRJNA994913 | ENA
GenomicsYTHDC1 cooperates with the THO complex to prevent RNA damage-induced DNA breaks
YTHDC1 cooperates with the THO complex to prevent RNA damage-induced DNA breaks
PRJNA1193090 | ENA
UnknownTHOC2 and THOC5 Regulate Stemness and Radioresistance in Triple-Negative Breast Cancer.
Not available
S-EPMC8693071 | biostudies-literature
UnknownTHOC3 interacts with YBX1 to promote lung squamous cell carcinoma progression through PFKFB4 mRNA modification.
Not available
S-EPMC10374565 | biostudies-literature
ProteomicsRNA helicase Ighmbp2 regulates THO complex to ensure cellular mRNA homeostasis
RNA helicases constitute a large protein family implicated in cellular RNA homeostasis and disease development. Here we show that the RNA helicase Ighmbp2, linked to the neuromuscular disorder SMARD1 (DSMA1) associates with polysomes and impacts on translation of cellular mRNAs containing short, GC-...
ORGANISM(S): Homo sapiens (Human) 
2024-02-15 | PXD043336 | Pride
Thoc Mrna-homeostasis Ighmbp2 Smard1 Rna helicase 
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