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ProteomicsTargeting peptidyl-arginine deiminase 4 suppresses SARS-CoV-2 replication and modulates the inflammatory response
This project presents a comprehensive, quantitative proteomics and citrullinome profiling study designed to define how viral infection remodels host protein citrullination and related cellular pathways. The experimental design integrates in vitro and in vivo models of infection, including cultured h...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2026-01-30 | PXD072601 | Pride
Protein arginine deiminase Inflammation Covid Lung Padi4 
TranscriptomicsInhibition of Met results in concomitant inhibition of Akt and STAT3 signaling pathways, while abrogation of negative feedback permits Erk reactivation
Amplification and activation of the Met receptor tyrosine kinase occurs up to 23% of gastric cancers, suggesting that Met is a therapeutic target in these cancers. However, the steady-state signaling events that occur during chronic Met activation, and mechanisms for resistance to Met small-molecul...
ORGANISM(S): Homo sapiens 
2014-05-19 | E-GEOD-54532 | biostudies-arrayexpress
MetabolomicsField study of the fire blight resistant cisgenic apple line C44.4.146

Cisgenesis, the genetic modification of a plant with genes from a sexually compatible plant, was used to confer fire blight resistance to the cultivar 'Gala Galaxy' by amendment of the resistance gene FB_MR5, resulting in the line C44.4146. To verify whether cisgenesis changed other tree-, flower...

2022-12-19 | MTBLS5810 | MetaboLights
ProteomicsHuman cytomegalovirus-induced host protein citrullination is crucial for viral replication
Citrullination is the conversion of arginine-to-citrulline by protein arginine deiminases (PADs), whose dysregulation is implicated in the pathogenesis of various types of cancers and autoimmune diseases. Consistent with the ability of human cytomegalovirus (HCMV) to induce post-translational modifi...
ORGANISM(S): Homo sapiens (Human) 
2021-07-20 | PXD025818 | Pride
Citrullination 
ProteomicsHuman cytomegalovirus-induced host protein citrullination is crucial for viral replication
Citrullination is the conversion of arginine-to-citrulline by protein arginine deiminases (PADs), whose dysregulation is implicated in the pathogenesis of various types of cancers and autoimmune diseases. Consistent with the ability of human cytomegalovirus (HCMV) to induce post-translational modifi...
ORGANISM(S): Homo sapiens (Human) 
2021-07-20 | PXD025803 | Pride
Hcmv Ifit1 Citrullination 
TranscriptomicsHematopoietic Stem Cell Differentiation Regulated by a Single Ubiquitin Ligase: Substrate Complex
Hematopoietic stem cell (HSC) differentiation is regulated by cell-intrinsic and extrinsic cues. In addition to transcriptional regulation, post-translational regulation may also control HSC differentiation. To test this hypothesis, we visualized ubiquitin-regulated protein stability of a single tra...
ORGANISM(S): Mus musculus 
2010-03-07 | E-GEOD-19502 | biostudies-arrayexpress
UnknownHuman cytomegalovirus-induced host protein citrullination is crucial for viral replication.
Not available
S-EPMC8222335 | biostudies-literature
UnknownCitrullination profile analysis reveals peptidylarginine deaminase 3 as an HSV-1 target to dampen the activity of candidate antiviral restriction factors.
Not available
S-EPMC10727434 | biostudies-literature
Proteomicshigh fiber diet mice methanol extracts
comparison between high fiber diet and ctrl mice methanol extraction, q exactive hf, 28 min method
ORGANISM(S): Mus Sp. (ncbitaxon:10095) 
2021-02-16 | MSV000086890 | MassIVE
MetabolomicsGNPS - high fiber diet mice methanol extracts
comparison between high fiber diet and ctrl mice methanol extraction, q exactive hf, 28 min method
ORGANISM(S): Mus Sp. (ncbitaxon:10095) 
2021-02-16 | MSV000086890 | GNPS
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