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ProteomicsIdentifying and characterising Thrap3, Bclaf1 and Erh direct interactions using cross-linking mass spectrometry
Cross-linking mass spectrometry (XL-MS) is a powerful technology capable of yielding structural insights across the complex cellular protein interaction network. We performed XL-MS using MS-cleavable cross-linker disuccinimidyl sulfoxide (DSSO) on endogenous affinity-purified BAF complex. We identif...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-24 | PXD027611 | Pride
Clms cross-linking mass spectrometry Endogenous complexes Erh Dsso Xl-ms Thrap3 Bclaf1 
ProteomicsInhibition of a novel CLK1-THRAP3-PPARγ axis improves insulin sensitivity
CLK1 plays a critical role in controlling energy expenditure through the CLK1-Thrap3-PPARγ axis.
ORGANISM(S): Homo Sapiens Mus Musculus 
2021-08-16 | PXD027958 |
GenomicsPhosphorylation-dependent THRAP3 RNA-binding in prostate cancer
Phosphorylation-dependent THRAP3 RNA-binding in prostate cancer
PRJNA1365714 | ENA
ProteomicsProteomic Analysis of Downstream Proteins Regulated by THRAP3 in THP-1 Cells
This study aimed to analyze the downstream proteins regulated by THRAP3 in THP-1 cells using proteomics. THP-1 cells were divided into control and KO groups (with 3 biological replicates each, transfected with sgNC or sgTHRAP3 respectively). After cell lysis, trypsin digestion, Tandem Mass Tags labe...
ORGANISM(S): Homo sapiens (Human) 
2025-12-11 | PXD069724 | Pride
Proteomics Thrap3 Tandem mass tags Thp-1 cells Lc-ms/ms 
GenomicsSENP3 Drives HCC Redox Adaptation via THRAP3/NRF1 Axis
SENP3 Drives HCC Redox Adaptation via THRAP3/NRF1 Axis
PRJNA1244237 | ENA
GenomicsFunctional Role of THRAP3 in Modulating Thyroid Hormone–Mediated Gene Networks in C2C12 Myotubes
Functional Role of THRAP3 in Modulating Thyroid Hormone–Mediated Gene Networks in C2C12 Myotubes
PRJNA1310944 | ENA
TranscriptomicsFunctional Role of THRAP3 in Modulating Thyroid Hormone–Mediated Gene Networks in C2C12 Myotubes
Thyroid hormone (TH) secreted by the thyroid gland plays essential roles in regulating metabolism, development, and nervous system function. Thyroid hormone receptor-associated protein 3 (THRAP3) is a nuclear coactivator that interacts with the thyroid hormone receptor (TR) and facilitates target ge...
ORGANISM(S): Mus musculus 
2025-12-11 | GSE306461 | GEO
UnknownThrap3 promotes R-loop resolution via interaction with methylated DDX5.
Not available
S-EPMC8569202 | biostudies-literature
UnknownThrap3 promotes nonalcoholic fatty liver disease by suppressing AMPK-mediated autophagy.
Not available
S-EPMC10474030 | biostudies-literature
GenomicsPhosphorylation-dependent regulation of gene expression and alternative splicing by THRAP3 in prostate cancer
Phosphorylation-dependent regulation of gene expression and alternative splicing by THRAP3 in prostate cancer
PRJNA1472646 | ENA
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