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MetabolomicsSimultaneous Membrane and RNA Binding by Tick-Borne Encephalitis Virus Capsid Protein

Tick-borne encephalitis virus is an enveloped, pathogenic, RNA virus in the family Flaviviridae, genus Flavivirus. Viral particles are formed when the nucleocapsid, consisting of an RNA genome and multiple copies of the capsid protein, buds through the endoplasmic reticulum membrane and acquires ...

2023-01-06 | MTBLS6076 | MetaboLights
TranscriptomicsEarly immunologic events at the tick-host interface
Ixodes species ticks are competent vectors of tick-borne viruses including tick-borne encephalitis and Powassan encephalitis.  Tick saliva has been shown to facilitate and enhance viral infection.  This likely occurs by saliva-mediated modulation of host responses into patterns favorable for viral i...
ORGANISM(S): Mus musculus 
2012-12-21 | E-GEOD-39100 | biostudies-arrayexpress
ProteomicsMetabolic pathways affected by Anaplasma in tick cells
Anaplasma phagocytophilum is an emerging zoonotic pathogen that causes human granulocytic anaplasmosis. These intracellular bacteria establish infection by affecting cell function in both the vertebrate host and the tick vector, Ixodes scapularis. Previous studies have characterized the tick transcr...
ORGANISM(S): Ixodes scapularis (Black-legged tick) (Deer tick) 
2015-10-05 | PXD002181 | Pride
Ixodes scapularis ise6 cells Anaplasma phagocytophilum Rp-lc-lit-ms 
TranscriptomicsIntegrated metabolomics, transcriptomics and proteomics identifies metabolic pathways affected by Anaplasma phagocytophilum infection in tick cells
Anaplasma phagocytophilum is an emerging zoonotic pathogen that causes human granulocytic anaplasmosis. These intracellular bacteria establish infection by affecting cell function in both the vertebrate host and the tick vector, Ixodes scapularis. Previous studies have characterized the tick transcr...
ORGANISM(S): Ixodes scapularis 
2016-01-06 | E-GEOD-68881 | biostudies-arrayexpress
TranscriptomicsTranscriptional responses in bovine skin during blood feeding of the cattle tick, Rhipicephalus microplus.
We examined gene expression induced by Rhipicephalus microplus bites on host skin of tick-resistant and tick-susceptible breeds of bovines, Nelore and Holstein respectively, when they underwent a primary infestation.
ORGANISM(S): Bos taurus 
2017-04-02 | E-MTAB-4908 | biostudies-arrayexpress
ProteomicsRickettsia rickettsii modulates the proteome of tick cells towards a protective state against apoptosis
Different types of cell death, including apoptosis, play an important role in the immune defense of arthropods, as infected cells are eliminated, preventing the dissemination of the infectious agent throughout the animal body. The apoptosis can be triggered by two main pathways: the intrinsic or mit...
ORGANISM(S): Rickettsia rickettsii 
2021-09-09 | PXD017942 | Pride
Rickettsiae Tick Apoptosis Proteome 
TranscriptomicsGlobal gene transcription analysis of Anaplasma phagocytophilum in tick and human cells using tiling microarrays
A whole genome tiling microarray based on the published sequence of the Anaplasma phagocytophilum (Ap) strain Hz genome was used to measure transcriptional activity of Ap grown to late stage in three cell lines representing the diversity of host cells naturally infected by Ap: two human cell lines, ...
ORGANISM(S): Anaplasma phagocytophilum HZ 
2008-08-04 | E-GEOD-11487 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of the host cutaneous response to Ixodes scapularis
Introduction: Ixodes scapularis ticks are hematophagous arthropods capable of transmitting many infectious agents to humans. The process of blood feeding is an extended and continuous interplay between tick and host responses. While this process has been studied extensively in vitro, no global under...
ORGANISM(S): Mus musculus 
2012-02-17 | E-GEOD-33345 | biostudies-arrayexpress
ProteomicsTwo Types of Axonal Muscarinic Acetylcholine Receptors Mediate Formation of Saliva Cocktail in the Tick Ixodes ricinus
The long blood feeding duration of hard ticks relies on the continuous modulation of saliva composition to manipulate host haemostatic and immune systems. While the exogenous muscarinic acetylcholine receptor (mAChR) agonist, pilocarpine, is a potent inducer of tick salivation, the underlying contro...
ORGANISM(S): Ixodes ricinus 
2026-02-05 | PXD055362 | Pride
Synganglion Muscarinic receptors Neurosecretory cells Pharmacology Tick Axons Saliva Salivary gland acini 
TranscriptomicsTranscription profiling of Bos taurus white blood cells from Brahman and Holstein-Friesian cattle infested with the cattle tick Rhipicephalus microplus
This trial was undertaken to examine the perhipheral cellular and antibody response of cattle following infestation with the cattle tick, Rhipicephalus microplus. The information from the Affymetrix gene expression data is used to complement other measurements of immune function such as cellular sub...
ORGANISM(S): Bos indicus 
2009-01-13 | E-GEOD-13725 | biostudies-arrayexpress
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