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TranscriptomicsEarly immunologic events at the tick-host interface
Ixodes species ticks are competent vectors of tick-borne viruses including tick-borne encephalitis and Powassan encephalitis.  Tick saliva has been shown to facilitate and enhance viral infection.  This likely occurs by saliva-mediated modulation of host responses into patterns favorable for viral i...
ORGANISM(S): Mus musculus 
2012-12-21 | E-GEOD-39100 | biostudies-arrayexpress
ProteomicsTick host range adaptation: changes in protein profiles in Ixodes scapularis and Amblyomma americanum saliva during stimulation to feed on different hosts
Understanding the molecular basis of how the tick adapts to feed on different animal hosts is central to understanding tick and tick-borne disease (TBD) epidemiology. Tick adaptation to feed on vertebrate hosts is regulated by tick secretion of multiple tick saliva proteins (TSPs) and other molecule...
ORGANISM(S): Ixodes scapularis (Black-legged tick) (Deer tick) Amblyomma americanum 
2022-02-28 | PXD007712 | Pride
Tick-host relationship Saliva Tick Proteomic Host adaptation 
ProteomicsBorrelia burgdorferi infected Ixodes scapularis nymph saliva proteome
Lyme disease (LD) is one of the most important human vector-borne diseases in North America. Since transmission of Borrelia burgdorferi (Bb), the causative agent of LD, is influenced by yet unknown tick saliva proteins (TSP), the discovery and characterization of such TSPs are highly sought after fo...
ORGANISM(S): Ixodes scapularis (Black-legged tick) (Deer tick) Borreliella burgdorferi Oryctolagus cuniculus (Rabbit) 
2021-09-10 | PXD023940 | Pride
Borrelia burgdorferi Rabbit host Tick saliva 
ProteomicsTwo Types of Axonal Muscarinic Acetylcholine Receptors Mediate Formation of Saliva Cocktail in the Tick Ixodes ricinus
The long blood feeding duration of hard ticks relies on the continuous modulation of saliva composition to manipulate host haemostatic and immune systems. While the exogenous muscarinic acetylcholine receptor (mAChR) agonist, pilocarpine, is a potent inducer of tick salivation, the underlying contro...
ORGANISM(S): Ixodes ricinus 
2026-02-05 | PXD055362 | Pride
Synganglion Muscarinic receptors Neurosecretory cells Pharmacology Tick Axons Saliva Salivary gland acini 
ProteomicsIxodes Scapularis tick saliva proteins sequentially secreted every 24h during blood feeding
Ixodes scapularis is the most medically important tick species and transmits five of the 14 reportable human tick borne diseases (TBD) in the USA. This study describes LC-MS/MS identification of 582 tick- and 83 rabbit proteins in saliva of I. scapularis ticks that fed for 24, 48, 72, 96, and 120h, ...
ORGANISM(S): Ixodes scapularis (Black-legged tick) (Deer tick) 
2015-12-11 | PXD003214 | Pride
Tick feeding physiology Tick saliva proteome Ixodes scapularis 
ProteomicsA simple non-invasive method to collect soft tick saliva reveals differences in Ornithodoros moubata saliva composition between ticks infected and uninfected with Borrelia duttonii spirochetes
We developed a new simple method to assess the composition of proteins in the Ornithodoros moubata saliva. To collect naturally expectorated saliva from the ticks, we employed an artificial membrane feeding technique using a simple, chemically defined diet and submitted the collected native saliva s...
ORGANISM(S): Ornithodoros moubata Borrelia 
2023-01-10 | PXD038824 | Pride
Relapsing fever borrelia Artificial membrane feeding Ornithodoros moubata Saliva Infected Tick Lc-ms analysis Borrelia duttonii Spirochetes 
ProteomicsProteomic analysis of exosome-like vesicles isolated from saliva of the tick Haemaphysalis longicornis
In this study, extracellular vesicles were isolated from tick saliva and were analyzed for the presence of proteins. LC-MS/MS identified proteins within tick-derived EVs which may be used by tick in modulating host responses.
ORGANISM(S): Haemaphysalis Longicornis 
2020-04-28 | PXD018853 |
ProteomicsProteomic analysis of exosome like vesicles isolated from saliva of the tick Haemaphysalis longicornis
In this study, we show for the first time that the tick Haemaphysalis longicornis secretes EVs in saliva that resembles exosomes. EVs were purified from pilocarpine induced saliva of partially engorged H. longicornis ticks. Electron microscopy analysis revealed the presence of exosome-like vesicles ...
ORGANISM(S): Haemaphysalis Longicornis 
2020-07-10 | PXD020300 |
ProteomicsTime-resolved proteomic profile of Amblyomma americanum tick saliva during feeding Running Title: Proteins in tick saliva every 24 h during feeding
Pioneering studies (PXD014844) have identified many interesting molecules by LC-MS/MS proteomics, but the protein databases used to assign mass spectra were based on short Illumina reads of the Amblyomma americanum transcriptome and may not have captured the diversity and complexity of longer transc...
ORGANISM(S): Amblyomma americanum 
2020-01-23 | PXD014844 | Pride
Tick-feeding Ticks Saliva Proteome 
ProteomicsQualitative and quantitative proteomics informed by transcriptomics insight into the proteome of Ornithodoros erraticus adult tick saliva.
Anti-tick vaccines have proved to be an effective and sustainable method for the control of tick infestations and tick-borne diseases with clear advantages over the application of chemical acaricides (Šmit and Postma, 2016; de la Fuente, 2018; Ndawula and Tabor, 2020). Moreover, the efficacy of acar...
ORGANISM(S): Ornithodoros erraticus 
2022-02-17 | PXD027367 | Pride
Lc msms Label free quantitaion Dia Ornithodoros erraticus proteome Swath 
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