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ProteomicsPhosphoproteomics of C.elegans RNA binding protein mutants
Nonsense-mediated mRNA decay (NMD) monitors the quality of transcriptomes and degrades messenger RNAs containing splicing errors or premature stop codons. NMD thus dictates the severity and outcome of genetic disorders, gene edits and knockouts as well as the prevalence of neoantigens. Central to th...
ORGANISM(S): Caenorhabditis elegans 
2022-08-12 | PXD022616 | Pride
C.elegans 
ProteomicsSister chromatid exchanges independent of canonical homologous recombination factors.
Sister chromatid exchanges (SCEs) are a product of joint DNA molecules resolution, and are considered to require homologous recombination (HR). Canonical HR factors BRCA1, BRCA2 and RAD51 were indeed essential for SCE induction in response to irradiation-induced DNA breaks. By contrast, replication-...
ORGANISM(S): Xenopus laevis (African clawed frog) 
2023-03-11 | PXD028670 | Pride
Cross-over Interphase Xenopus laevis Ms Mitosis Hr Sce Synthetic lethality Parp inhibitors Genome stability Biotin 
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