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ProteomicsPTBP1 and PTBP2 associate with distinct proteins and have distinct post-translational modifications in nuclear neuronal extract.
PTBP1 and PTBP2 are highly conserved paralogs, yet exhibit distinct splicing patterns. Here we use mass spectrometry to show that PTBP1 and PTBP2 interact with distinct proteins and undergo distinct post translational modifications under splicing conditions in neuronal nuclear extract.
ORGANISM(S): Homo sapiens (Human) 
2026-02-09 | PXD058740 | Pride
Post-translational modificantions Ptbp1 Mass spectrometry Splicing Ptbp2 Protein-protein interactions 
ProteomicsCharacterization of Heterorhabditis bacteriophora Response to Insect-Derived and Non-Biological Stimuli: Insights into Nematode Recovery and Released Proteins
Entomopathogenic nematodes (EPNs) are gaining significant popularity as biocontrol agents due to their ability to rapidly kill insect hosts. These nematodes produce bioactive molecules known as excreted/secreted products (ESPs) that help them overcome host immune defenses. Understanding the mechanis...
ORGANISM(S): Heterorhabditis bacteriophora 
2025-02-10 | PXD056325 | Pride
Nematode Timtof Proteomic Heterorhabditis 
ProteomicsRare ADAR1 loss-of-function variants alter RNA editing and drive interferondependent inflammation in psoriasis
In 4 unrelated pedigrees, we report rare heterozygous loss-of-function ADAR1 mutations cosegregating with autosomal dominant, early onset psoriasis and increased type I interferon (IFN)-stimulated gene (ISG) transcripts in skin lesions and/or blood. We identified 6 additional variants in a psoriasis...
ORGANISM(S): Homo sapiens (Human) 
2026-04-27 | PXD065122 | Pride
Keratinocyte Melanocyte Timtof pro Adar1 
ProteomicsMicrobial alginate foraging is conserved in geographically and taxonomically distinct ruminant microbiomes
Saccharina latissima is a brown alga commonly found in the North Atlantic, Arctic and Pacific oceans. Alginate constitutes a substantial portion of the cell wall of S. latissima, and its digestion requires a specific set of enzymes, alginate lyases. We investigated if and how S. latissima is metabol...
ORGANISM(S): organismal metagenomes 
2026-04-16 | PXD059090 | Pride
ProteomicsSaturated fat exacerbates mitochondrial dysfunction through remodelling of ATP production and inflammation in Barrett’s oesophagus compared to monounsaturated fat, particularly in contrast to oesophageal adenocarcinoma
Obesity-related oesophageal adenocarcinoma (OAC), arising from Barret’s oesophagus (BO), incidence rates are rising coincident with high-fat diets. However, adipose tissue phenotype drives metabolic characteristics. Prior feeding studies demonstrated that obesogenic diets enriched in saturated fatty...
ORGANISM(S): Homo sapiens (Human) 
2025-06-16 | PXD055313 | Pride
Oesophageal adenocarcinoma Metabolism Cancer Saturated fatty acids Inflammation Diet Barrett’s oesophagus Obesity Monounsaturated fatty acids 
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