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MetabolomicsCharacterization of Whole Blood EVs Using PRotein Organic Solvent PRecipitation

Blood plays a vital role in diagnostic medicine by providing essential information for assessing health and diagnosing various conditions. Routine blood tests can reveal important biomarkers that support early diagnosis and timely intervention. Recently, extracellular vesicles (EVs) have emerged ...

2026-08-24 | MTBLS12801 | MetaboLights
MetabolomicsThe untargeted metabolites of field EVs from Xinglinwan Reservoir, Xiamen, China.

Microorganisms secrete extracellular vesicles (EVs) that transport bioactive molecules such as proteins, metabolites, and enzymes. While their functions are well studied in model microbes, their ecological contributions to natural ecosystems remain largely unexplored.To address this issue, we per...

2026-01-21 | MTBLS12874 | MetaboLights
MetabolomicsBacteria regulate aging physiology in microalgae via induced vesicle production and the methionine cycle (Metabolomics profiling of FACS purified EVs)

In annually reoccurring patterns, microalgae form blooms that persist and decline thereby contributing massively to global biogeochemical cycles. The decline of blooms is mainly caused by nutrient limitation and goes ahead with the aging of individual algal cells. Nutrient intake can re-initiate ...

2024-05-07 | MTBLS5401 | MetaboLights
TranscriptomicsDifferentially enriched miRNAs in EVs derived from young and aged osteocytes of mice
Vascular calcification often occurs with osteoporosis, a contradictory association called “calcification paradox”. We find that extracellular vesicles (EVs) released from aged bone matrix (AB-EVs) during bone resorption favor adipogenesis rather than osteogenesis of BMSCs and augment calcification o...
ORGANISM(S): Mus musculus 
2022-02-15 | E-MTAB-11417 | biostudies-arrayexpress
TranscriptomicsOsteoblasts secrete miRNA-containing extracellular vesicles that enhance expansion of human umbilical cord blood cells
Osteolineage cells represent one of the critical bone marrow niche components that support maintenance of hematopoietic stem and progenitor cells (HSPCs). Recent studies demonstrate that extracellular vesicles (EVs) regulate stem cell development via horizontal transfer of bioactive cargo, including...
ORGANISM(S): Homo sapiens 
2016-10-05 | E-MTAB-4560 | biostudies-arrayexpress
TranscriptomicsNanoString assays of miRNA in MCF7 and MCF10A cells and in extracellular vesicles (EVs) derived from these cells.
The goal of this study is to identify unique miRNA profiles of EVs from MCF7 and MCF10A cells that distinguish their cellular origin. 654 human mature miRNAs were analyzed in NanoString assays to identify miRNA with high abundance in MCF7 EVs and the greatest fold change for MCF7 EVs relative to MCF...
ORGANISM(S): Homo sapiens 
2015-02-21 | E-GEOD-66165 | biostudies-arrayexpress
TranscriptomicsRNA-Seq of tissue and plasma extracellular vesicles of breast cancer patients at the time of diagnosis and after the breast surgery
In the current study, we performed deep sequencing analysis of the RNA cargo of plasma EVs collected at the time of diagnosis, during and after the NAC and up to 18 months after the surgery and matched tumor and normal tissues from 35 patients with locally advanced BC, and 30 cancer-free females.
ORGANISM(S): Homo sapiens 
2022-10-24 | E-MTAB-12014 | biostudies-arrayexpress
ProteomicsTMT-based quantitative proteomic analysis of extracellular vesicles (EVs) released from brown/white adipose tissue following cold exposureTMT-based quantitative proteomic analysis of extracellular vesicles (EVs) released from brown/white adipose tissue following cold exposure
The proteome cargo of extracellular vesicles released from brown adipose tissue (BAT) and from white adipose tissue (WAT) of mice subjected to cold exposure (4°C) was analysed by a TMT-based quantitative proteomic procedure in order to obtain new information on the processes of thermogenesis.
ORGANISM(S): Mus musculus (Mouse) 
2022-05-20 | PXD026080 | Pride
Tmt Lc-ms Bat/wat Evs 
MetabolomicsIndustrial by-products as a novel circular source of biocompatible extracellular vesicles

Extracellular vesicles (EVs) constitute an intricate system of molecular exchange that has recently gained tremendous interest. However, sustainable sources of safe biological EVs remain scarce and elusive. In this study we explore and define the use of food industry byproducts (BP) as a circular...

2022-05-17 | MTBLS2801 | MetaboLights
ProteomicsEffect of cryopreservation of lysate/tissue on EOC tissue-derived EVs
We optimized a method previously developed to extract EVs from epithelial ovarian cancer (EOC) tissues and investigated whether cryopreservation of EOC tissues in clinical practice affects the phenotypes, contents, and biological functions of subsequently extracted EVs.
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD039422 | Pride
Human Ovarian cancer Extracellular vesicles Lc-ms/ms 
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