Sort   by:  
 Page size 
TranscriptomicsComplete TLR3 deficiency
The objective of this study is to study the Toll-like receptor 3 (TLR3)-dependent gene expression in human fibroblast cells and peripheral blood mononuclear cells (PBMCs) Fibroblast cells and PBMCs from donors with autosomal recessive (AR) complete TLR3 deficiency and autosomal dominant (AD) partial...
ORGANISM(S): Homo sapiens 
2011-11-02 | E-GEOD-30951 | biostudies-arrayexpress
TranscriptomicsImpaired TLR3-mediated immune responses from macrophages of patients chronically infected with Hepatitis C virus
Hepatitis C virus (HCV) is the most common chronic blood-borne infection in the United States with the majority of patients becoming chronically infected and a subset (20%) progressing to cirrhosis and hepatocellular carcinoma. Individual variations in immune responses may help define successful res...
ORGANISM(S): Homo sapiens 
2013-03-05 | E-GEOD-40812 | biostudies-arrayexpress
TranscriptomicsGene expression signatures for murine alveolar type II lung epithelial cells after tumor bearing
To determine the influence of primary tumors on pre-metastatic lungs, we have employed whole genome microarray expression profiling as a discovery platform to identify gene signatures of alveolar type II epithelial cells (AT-II) in TLR3 deficient mice (Tlr3-/-) and wide-type (WT) littermates with tu...
ORGANISM(S): Mus musculus 
2016-08-10 | E-GEOD-76397 | biostudies-arrayexpress
TranscriptomicsImpaired intrinsic immunity to HSV-1 in human iPSC-derived TLR3-deficient CNS cells
In the course of primary infection with herpes simplex virus 1 (HSV-1), children with inborn errors of the TLR3- and UNC-93B-dependent induction of IFN-α/β and/or IFN-λ immunity are prone to HSV-1 encephalitis (HSE) 1-3. The cells responsible for HSE in these children have yet to be identified. We t...
ORGANISM(S): Homo sapiens 
2012-11-29 | E-GEOD-40593 | biostudies-arrayexpress
ProteomicsHuman mesenchymal stromal cell TLR3 ligand-treated LC-MS/MS
Human mesenchymal stromal cells (MSCs) were treated with TLR3 ligand. LS-MS/MS analysis was performed to reveal changes in proteins related to the immunosuppressive properties of MSCs and to better understand the mechanisms underlying the activation of these properties.
ORGANISM(S): Homo sapiens (Human) 
2023-11-09 | PXD044795 | Pride
Human Mscs Tlr3 Lc-ms/ms 
TranscriptomicsGene profiling in the colon after depletion and activation of TLR3 and TLR7 signals
TLR3 and TLR7 are critical recognition receptor which reacts with viruses. TLR3 and TLR7 contribute to many immunological pathway. Especially, TLR3 and TLR7 are clearly involved in the regulation of innate immunity in the gut. To identify the downstream target of TLR 3 and TLR7 in the IBD, we carrie...
ORGANISM(S): Mus musculus 
2016-07-05 | E-GEOD-79241 | biostudies-arrayexpress
TranscriptomicsmicroRNA expression profiling of small intestine of Tlr3+/+ and Tlr3-/- mice after total body g-irradiation
Microarray was performed to comprehensively examine microRNA induction in murine small intestine after exposure to total body g-irradiation. Small intestines were collected from Tlr3+/+ and Tlr3-/- mice at 0 and 6 hr after exposure to 10 Gy of total body g-irradiation. Samples were pooled from 3 mic...
ORGANISM(S): Mus musculus 
2015-02-01 | E-GEOD-42916 | biostudies-arrayexpress
TranscriptomicsIn vitro responses of fibroblasts from patients with TBK1 deficiency after TLR3 dependent and independent stimuli
We report here two unrelated HSE patients carrying different heterozygous mutations (D50A and G159A) in TBK1, the gene encoding TANK-binding kinase 1, a kinase at the crossroads of multiple IFN-inducing signaling pathways. Both mutant TBK1 alleles are loss-of-function, but through different mechanis...
ORGANISM(S): Homo sapiens 
2012-07-29 | E-GEOD-38652 | biostudies-arrayexpress
GenomicsAssessment of the impact of the TLR3 L412F variant in terms of TLR3-sensitive transcript induction
Assessment of the impact of the TLR3 L412F variant in terms of TLR3-sensitive transcript induction
PRJNA892959 | ENA
ProteomicsPhosphorylated TLR3 nuclear translocation in cancer cell promotes metastasis and chemoresistance
Phosphorylated TLR3 nuclear translocation in cancer cell promotes metastasis and chemoresistance
ORGANISM(S): Homo Sapiens 
PXD064767 |
Sort   by:  
 Page size