Sort   by:  
 Page size 
ProteomicsIdentification of TMEM106B-binding proteins in mouse brain
TMEM106B is an endolysosomal transmembrane protein associated with many brain disorders, such as frontotemporal lobar degeneration, Alzheimer’s disease, and hypomyelinating leukodystrophy. In addition, recent cryo-EM studies have identified amyloid fibrils of carboxyl-terminal TMEM106B in the brains...
ORGANISM(S): Mus musculus (Mouse) 
2024-08-06 | PXD043192 | Pride
Mouse Brain Lysosome Lc-ms/ms 
ProteomicsThe major TMEM106B dementia risk allele affects TMEM106B protein levels, fibril formation, and myelin lipid homeostasis in the ageing human hippocampus
Background: The risk for dementia increases exponentially from the seventh decade of life. Identifying and understanding the biochemical changes that sensitize the ageing brain to neurodegeneration will provide new opportunities for dementia prevention and treatment. This study aimed to determine ho...
ORGANISM(S): Homo sapiens (Human) 
2023-09-21 | PXD043880 | Pride
Lipidomic Sphingolipid Hippocampus Myelin Tmem106b Proteomic Ageing Neurodegeneration 
GenomicsLoss of Tmem106b leads to cerebellum Purkinje cell death and motor deficits
Loss of Tmem106b leads to cerebellum Purkinje cell death and motor deficits
PRJNA693266 | ENA
GenomicsLoss of Tmem106b leads to myelination deficits: implications for FTD treatment strategies
Loss of Tmem106b leads to myelination deficits: implications for FTD treatment strategies
PRJNA606744 | ENA
TranscriptomicsLoss of Tmem106b leads to myelination deficits: implications for FTD treatment strategies
Genetic variants that define two distinct haplotypes at the TMEM106B locus have been implicated in multiple neurodegenerative diseases and in healthy brain aging. In frontotemporal dementia (FTD), the high expressing TMEM106B risk haplotype was shown to increase susceptibility for FTD with TDP-43 in...
ORGANISM(S): Mus musculus 
2020-02-15 | GSE145314 | GEO
UnknownMyristoylation of TMEM106B by NMT1/2 regulates TMEM106B trafficking and turnover.
Not available
S-EPMC12268641 | biostudies-literature
UnknownTMEM106B p.T185S regulates TMEM106B protein levels: implications for frontotemporal dementia.
Not available
S-EPMC3766501 | biostudies-literature
GenomicsTMEM106B coding variant is protective and deletion detrimental in a mouse model of tauopathy
TMEM106B coding variant is protective and deletion detrimental in a mouse model of tauopathy
PRJNA925897 | ENA
UnknownC-terminal TMEM106B fragments in human brain correlate with disease-associated TMEM106B haplotypes.
Not available
S-EPMC10545506 | biostudies-literature
TranscriptomicsLoss of Tmem106b leads to cerebellum Purkinje cell death and motor deficits
The loss of Tmem106b results in an age-dependent loss of cerebellar Purkinje cells accompanied with motor function deficits. Tmem106b deficiency also results in lysosomal enlargement in both Purkinje cells and microglia, and increased neuroinflammation including complement system activation. These d...
ORGANISM(S): Mus musculus 
2021-01-20 | GSE165105 | GEO
Sort   by:  
 Page size