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ProteomicsComparative Proteomic and Transcriptomic Analysis of Follistatin-induced Skeletal Muscle Hypertrophy
Skeletal muscle, the most abundant body’s tissue, plays vital roles in locomotion and metabolism. Myostatin is a negative regulator of skeletal muscle mass. In addition to increase muscle mass, Myostatin inhibition impacts on muscle contractility and energy metabolism. To decipher the mechanisms of ...
ORGANISM(S): Mus musculus (Mouse) 
2017-08-17 | PXD005899 | Pride
Follistatin Mass spectrometry Microarray Skeletal muscle hypertrophy Myostatin 
ProteomicsAlteration of microbiota antibody-mediated immune selection contributes to dysbiosis in IBD
The goal of this project is to find out whether human intestinal IgA1 and IgA2 secretion, transport and reactivity towards the microbiota might be involved in dysbiosis induction during Crohn’s disease and Ulcerative colitis. Mass spectrometry was used to characterize SIgA from Crohn’s disease patie...
ORGANISM(S): Homo sapiens (Human) 
2022-06-27 | PXD024060 | Pride
Glycosylations Intestinal disease Immune mucosal response Iga modifications 
ProteomicsSynthesis of flavonol-bearing probes and chemical proteomic analysis of Asteraceae petals in search of flavonoid enzymes
In flowers of Asteraceae, yellow flavonols bearing an additional hydroxyl group at positions 6 or 8 (ring A) contribute to petal UV-absorbing pigmentation patterns, which play a crucial role in attracting pollinating insects. Understanding the biogenesis of these special flavonols requires the ident...
ORGANISM(S): Rudbeckia hirta Tagetes erecta 
2023-07-20 | PXD041520 | Pride
Natural products • plant polyphenols • proteomics • bioinformatics • biosynthesis of higher hydroxylated flavonols 
ProteomicsSuccessive protein extraction using hydroxylamine to increase the depth of proteome coverage in fresh, forensic and archaeological bones
Proteomics is continually being applied to a wider range of applications, now including the analysis of archaeological samples and anatomical specimens, in particular, collagen-containing tissues such as bones and teeth. Here we present the application of a chemi-cal digestion-based proteomics sampl...
ORGANISM(S): Bos taurus (Bovine) Homo sapiens (Human) 
2024-03-28 | PXD046969 | Pride
Hydroxylamine Collagen Archaeology Chemical digestion 
ProteomicsSpecies identification of ivory and bone museum objects using minimally invasive proteomics
Ivory is a highly prized material in many cultures since it can be carved into intricated designs and have a highly polished surface. Due to its popularity, the animals from which ivory can be sourced have started to come under threat. Identification of the ivory species is not only important for co...
ORGANISM(S): Bos taurus (Bovine) Physeter catodon Hippopotamus amphibius (Hippopotamus) Loxodonta africana (African elephant) Cervus elaphus hippelaphus Loxodonta cyclotis Elephas maximus indicus 
2024-02-05 | PXD042536 | Pride
Hippopotamus Ivory Elephant Minimally invasive 
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