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ProteomicsTOMM70 ImportOmics analysis of human mitochondria
The overall aim of the project is the definition and characterization of the mitochondrial proteome of human cells, referred to as MitoCoP. To this end, we combined complementary strengths of subtractive proteomics, ImportOmics and subcellular protein profiling in a global multidimensional classific...
ORGANISM(S): Homo sapiens (Human) 
2021-11-25 | PXD018122 | Pride
Proteomics Silac Mitochondria Importomics Rnai-mediated protein knockdown 
UnknownPatient-specific mutation of contact site protein Tomm70 causes neurodegeneration.
Not available
S-EPMC12067081 | biostudies-literature
UnknownDe novo mutations in TOMM70, a receptor of the mitochondrial import translocase, cause neurological impairment.
Not available
S-EPMC7268787 | biostudies-literature
ProteomicsProximity labeling reveals differential interaction partners of the human mitochondrial import receptor proteins TOMM20 and TOMM70
Import of most mitochondrial proteins requires that their precursor proteins are bound by the (peripheral) receptor proteins Tom20, Tom22, and Tom70. For budding yeast Tom20 and Tom70, there is evidence of specific yet overlapping substrate recognition, but no such data is available for metazoan cel...
ORGANISM(S): Homo sapiens (Human) 
2026-01-07 | PXD057097 | Pride
Human Tomm20 Lc-ms Proximity labeling Synj2bp Localized translation Tomm70 
UnknownMitochondrial Bioenergetics of Functional Wound Closure is Dependent on Macrophage-Keratinocyte Exosomal Crosstalk.
Not available
S-EPMC11544725 | biostudies-literature
UnknownMultiomics Identification of Potential Targets for Alzheimer Disease and Antrocin as a Therapeutic Candidate.
Not available
S-EPMC8539161 | biostudies-literature
UnknownFAM210B activates STAT1/IRF9/IFIT3 axis by upregulating IFN-α/β expression to impede the progression of lung adenocarcinoma.
Not available
S-EPMC11791038 | biostudies-literature
UnknownDevelopment and Validation of a Novel Mitophagy-Related Gene Prognostic Signature for Hepatocellular Carcinoma Based on Immunoscore Classification of Tumor.
Not available
S-EPMC8560278 | biostudies-literature
ProteomicsA large-scale map of transient and constitutive interactors of human TOM complex enabled by crosslinking
The translocase of the outer mitochondrial membrane (TOM) is the major entry gate for the over 1,000 proteins that are continuously being imported into the organelle. While the core TOM complex is evolutionarily preserved between yeast and human, the human mitochondrial proteome is significantly lar...
ORGANISM(S): Homo sapiens (Human) 
2026-03-17 | PXD065392 | Pride
Bottom-up ms Cross-linking ms Affinity purification ms Human mitochondria Tom complex 
UnknownGDP/GTP exchange factor MADD drives activation and recruitment of secretory Rab GTPases to Weibel-Palade bodies.
Not available
S-EPMC9153003 | biostudies-literature
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