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ProteomicsProximity labeling reveals differential interaction partners of the human mitochondrial import receptor proteins TOMM20 and TOMM70
Import of most mitochondrial proteins requires that their precursor proteins are bound by the (peripheral) receptor proteins Tom20, Tom22, and Tom70. For budding yeast Tom20 and Tom70, there is evidence of specific yet overlapping substrate recognition, but no such data is available for metazoan cel...
ORGANISM(S): Homo sapiens (Human) 
2026-01-07 | PXD057097 | Pride
Human Tomm20 Lc-ms Proximity labeling Synj2bp Localized translation Tomm70 
UnknownTOMM20 as a potential therapeutic target of colorectal cancer.
Not available
S-EPMC6941759 | biostudies-literature
UnknownAR antagonists develop drug resistance through TOMM20 autophagic degradation-promoted transformation to neuroendocrine prostate cancer.
Not available
S-EPMC10413764 | biostudies-literature
UnknownTOMM20 as a driver of cancer aggressiveness via oxidative phosphorylation, maintenance of a reduced state, and resistance to apoptosis.
Not available
S-EPMC12330931 | biostudies-literature
UnknownHsp70-Bim interaction facilitates mitophagy by recruiting parkin and TOMM20 into a complex.
Not available
S-EPMC10223935 | biostudies-literature
UnknownGsk3β and Tomm20 are substrates of the SCFFbxo7/PARK15 ubiquitin ligase associated with Parkinson's disease.
Not available
S-EPMC5260939 | biostudies-literature
UnknownMethylation quantitative trait loci within the TOMM20 gene are associated with metabolic syndrome-related lipid alterations in severely obese subjects.
Not available
S-EPMC4966599 | biostudies-literature
ProteomicsBiogenesis of Mitochondrial-Derived Vesicles (MDVs) – Novel Roles of GTPases MIRO1/2 and DRP1
MDVs are implicated in diverse physiological processes e.g. mitochondrial quality control and are linked to various neurodegenerative diseases. However, their specific cargo composition and complex molecular biogenesis is still unknown. Here we report for the first time the proteome and lipidome of ...
ORGANISM(S): Cercopithecus aethiops (Green monkey) (Grivet) 
2021-09-28 | PXD023077 | Pride
Qexactive hf-x Mitochondrion Mdv 
TranscriptomicsMitochondrial haplotype influences ovarian aging in genetically heterogeneous rats
Ovarian aging leads to permanent reproductive senescence and systemic hormonal changes that predispose to age-associated comorbidities. Despite these clinical implications, the intrinsic mechanisms driving age-related ovarian decline are poorly defined. Mitochondrial DNA (mtDNA) mutations and instab...
ORGANISM(S): Rattus norvegicus 
2026-09-17 | GSE328056 | GEO
UnknownStructure of the TPR domain of AIP: lack of client protein interaction with the C-terminal α-7 helix of the TPR domain of AIP is sufficient for pituitary adenoma predisposition.
Not available
S-EPMC3534021 | biostudies-literature
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