Sort   by:  
 Page size 
ProteomicsGlobal quantitative proteomics of mouse brain structures reveals significant alterations in expression of proteins involved in neuronal plasticity during aging
Aging is believed to be the result of alterations of protein expression and accumulation of changes in biomolecules. Although there are numerous reports demonstrating changes in protein expression in brain during aging, only few of them describe global changes in the protein level. Here, we present ...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2018-07-03 | PXD009792 | Pride
Hippocampus Cerebellum Total proteins approach (tpa) Aging Cortex Fasp Mouse brain 
ProteomicsInter-Laboratory Variability in the Madin-Darby Canine Kidney Cell ProteomeInter-Laboratory Variability in the Madin-Darby Canine Kidney Cell Proteome
Madin-Darby Canine Kidney (MDCK) cells are widely used to study epithelial cell functionality. Their low endogenous drug transporter protein levels make them an amenable system to investigate trans-epithelial permeation and drug transporter protein activity after their transfection. MDCK cells displ...
ORGANISM(S): Zea mays (Maize) 
2023-07-20 | PXD039552 | Pride
Label-free proteomics  total protein analysis (tpa)  mdck  epithelial proteome  adme protein abundances 
OtherAbsolute protein quantification allows differentiation of cell specific metabolic routes and functions.
Data from ProteomeXchange, PXD ID: PXD001352. Experiment: mouse, brain, file: 20140327_EXQ3_JRW_D75_L2.mzml. Published as part of Proteomics. 2014 Dec 5 . From the Abstract: {{i}} Total protein approach (TPA) is a proteomic method which allows calculation of concentrations of individual proteins an...
ORGANISM(S): Mus_musculus_viruses, Mouse 
GPM32310005401 | GPMDB
Resource Reanalysis 
ProteomicsCultured hippocampal neurons glial fibrillary acidic protein (GFAP)
Despite their widespread use as a research model, a comprehensive, quantitative proteomic profile of the cultured hippocampal neurons has remained unexplored. Here, we provide the first global proteomic characterization of primary murine hippocampal neurons cultured for 14 days under near-physiologi...
ORGANISM(S): Mus musculus (Mouse) 
2026-01-22 | PXD067465 | Pride
Proteomics Gfpa Neurons Hippocamp Lc-ms 
UnknownAbsolute quantitative proteomics using the total protein approach to identify novel clinical immunohistochemical markers in renal neoplasms.
Not available
S-EPMC8420025 | biostudies-literature
ProteomicsComparison of proteome composition of serum enriched in extracellular vesicles isolated from polycythemia vera patients and healthy controls
Extracellular vesicles (EVs), e.g., exosomes and microvesicles, are one of the main networks of intercellular communication. In myeloproliferative disorders, such as polycythemia vera (PV), excess of EVs originating from overabundant blood cells can directly contribute to thrombosis through their pr...
ORGANISM(S): Homo sapiens (Human) 
2019-05-13 | PXD013234 | Pride
Human plasma Extracellular vesicles Vesicles 
ProteomicsQuantitative Characterization of Clinically Relevant Drug-Metabolizing Enzymes and Transporters in Rat Liver and Intestinal Segments for Applications in PBPK Modeling
Rats are extensively used preclinical models for assessing drug pharmacokinetics (PK) and tissue distribution; however, a successful translation of the rat data requires information on the differences in drug metabolism and transport mechanisms between rats and humans. To partly fill this knowledge ...
ORGANISM(S): Rattus norvegicus (Rat) 
2025-02-05 | PXD039271 | Pride
Pbpk modeling Quantitative proteomics Drug metabolism Total protein approach Digoxin Drug transport Interspecies differences 
ProteomicsAbsolute Proteome Analysis of Hippocampus, Cortex and Cerebellum in Aged and Young Mice Reveals Changes in Energy Metabolism
Aging is associated with a general decline of cognitive functions, and it is widely accepted that this decline results from changes in expression of proteins involved in regulation of synaptic plasticity. However, several lines of evidence has accumulated that impaired function of aged brain may be ...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-17 | PXD025978 | Pride
Metabolism Hippocampus Cerebellum Aging Cortex 
ProteomicsComparative analysis of mouse muscles types
The dataset presents FASP- and LC-MS/MS-based analysis of whole lysates of tree types of mouse muscle tissue: white and red muscle fibers and heart muscle. The measurements were performed using five biological replicates for each tissue type. The dataset cover 7200 proteins. The data were used for ...
ORGANISM(S): Mus musculus (Mouse) 
2016-06-21 | PXD002152 | Pride
Skeletal muscle proteome Metabolism Quantitative proteomics Protein titer 'total protein approach' Glycolysis Heart muscle proteome Med fasp 
TranscriptomicsAnalyses of transcriptomic responses generated by hepatocarcinogens in a battery of liver-based in vitro models
For assessing the cancer-causing potential for humans of a chemical compound, the conventional approach is the use of the 2-year rodent carcinogenicity bioassay, thus alternatives such as in vitro toxicogenomics are highly desired. In the present study, the transcriptomics responses following exposu...
ORGANISM(S): Rattus norvegicus 
2013-02-20 | E-GEOD-40117 | biostudies-arrayexpress
Sort   by:  
 Page size