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ProteomicsQuantitative phosphoproteome analysis of cisplatin-induced apoptosis in Jurkat T cells
Reversible protein phosphorylation is one of the most important posttranslational modifications (PTMs) due to its vital role in cellular functions and signaling pathways. Protein phosphorylation is also known to be involved in the regulation of apoptosis. Previously, we have performed a SILAC-based ...
ORGANISM(S): Homo sapiens (Human) 
2017-05-11 | PXD004415 | Pride
: apoptosis Mass spectrometry Phosphorylation Cisplatin Phosphoproteomics 
ProteomicsTCR-engineered T cells targeting a shared β-catenin mutation eradicate solid tumors in vivo
CTNNB1/ ꞵ-catenin is mutated in 3.3% of solid cancers, with several recurrent gain-of-function mutations occurring early during cancer formation. This includes the shared driver mutation CTNNB1S37F, estimated to occur in >7000 new cancer cases in 2024 in the US. However, to offer attractive immunoth...
ORGANISM(S): Homo sapiens (Human) 
2025-07-15 | PXD054276 | Pride
Β-catenin In vivo T cells Immunotherapy 
UnknownChanges in Markers of T-Cell Senescence and Exhaustion With Atazanavir-, Raltegravir-, and Darunavir-Based Initial Antiviral Therapy: ACTG 5260s.
Not available
S-EPMC4978379 | biostudies-literature
ProteomicsEarly NK-cell and T-cell dysfunction marks progression to severe dengue in patients with obesity and healthy weight
Dengue is a mosquito-borne virus infection affecting half of the world’s population for which therapies are lacking. The role of T and NK-cells in protection/immunopathogenesis remains unclear for dengue for dengue. We performed a longitudinal phenotypic, functional and transcriptional analyses of T...
ORGANISM(S): Homo sapiens (Human) 
2025-05-21 | PXD061694 | Pride
Dengue Cd4+ t-cells Cd8+ t-cells Co-inhibitory receptors Cytotoxic cells Severe dengue biomarkers Nk-cells Type-i ifn 
ProteomicsPublic T cell epitopes shared among SARS-CoV-2 Public T cell epitopes shared among SARS-CoV-2 variants are presented on prevalent HLA class I alleles variants are presented on prevalent HLA class I alleles
In this project, we used MS-based immunopeptidomics and T-cell screening assays to identify SARS-CoV-2 epitopes. The MS identified epitopes were further valdiated for CD8 T cell immunogenecity. PBMC from a large number of patients infected with SARS-CoV-2 were used for valdiation of MS identifed and...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD028862 | Pride
Sars-cov-2 Lc-ms Immunopeptidomics 
ProteomicsA T-cell receptor targeting a shared neoantigen mediates elimination of primary human acute myeloid leukemia in vivo
This paper presents a T-cell receptor (TCR) reactive to the recurrent D835Y driver mutation in the FLT3 tyrosine-kinase domain. TCRFLT3D/Y-redirected T cells selectively eliminated primary human AML cells harboring the D835Y mutation in vitro and in vivo. The TCRFLT3D/Y cells rejected both CD34+ and...
ORGANISM(S): Homo sapiens (Human) 
2023-08-28 | PXD043908 | Pride
Human Prm Lc-ms Acute myeloid leukemia Cellular immunotherapy 
UnknownFirst decoding and characterization of the mitogenomes of the crocodile newts <i>Tylototriton anguliceps</i> and <i>T. ngoclinhensis</i> (Caudata, Salamandridae) from Vietnam and a phylogenetic assessment of the genus <i>Tylototriton</i>.
Not available
S-EPMC12776023 | biostudies-literature
UnknownUltrasmall Manganese Oxide Nanoparticles as Contrast Agents for T<sub>1</sub>‑T<sub>2</sub> Dual-Modal Magnetic Resonance Imaging.
Not available
S-EPMC12444676 | biostudies-literature
UnknownX-ray-irradiated K562 feeder cells for expansion of functional CAR-T cells.
Not available
S-EPMC9719861 | biostudies-literature
UnknownA systematic safety pipeline for selection of T-cell receptors to enter clinical use.
Not available
S-EPMC10444760 | biostudies-literature
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