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ProteomicsEV71 proteomics - Analysis of EV71 infection progression using triple-SILAC-based proteomics approach
Enterovirus 71 (EV71), a member of Picornaviridae, causes severe neurological and systemic illness in children. To better understand the virus-host cell interactions, we performed a triple-SILAC-based quantitative proteomics study monitoring host cell proteome changes after EV71 infection. Based on ...
ORGANISM(S): Homo sapiens (Human) 
2015-08-31 | PXD002483 | Pride
Enterovirus 71  tripletof 5600  triple silac  proteomics 
ProteomicsTriple SILAC exosomal quantitative proteomic analysis
Exosomes are 30-100 nm sized membrane vesicles released by cells into extracellular space and mediate the intercellular communication via transfer of proteins and RNAs. To better understand the function of these microvesicles in lung carcinogenesis, we employed a Triple SILAC quantitative proteomic ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-07-02 | MSV000079882 | MassIVE
ProteomicsTriple SILAC exosomal quantitative proteomic analysis
Exosomes are 30-100 nm sized membrane vesicles released by cells into extracellular space and mediate the intercellular communication via transfer of proteins and RNAs. To better understand the function of these microvesicles in lung carcinogenesis, we employed a Triple SILAC quantitative proteomic ...
ORGANISM(S): Homo sapiens (Human) 
2016-01-12 | PXD003001 | Pride
Non-small cell lung cancer Silac Exosomes Quantitative proteomics 
ProteomicsChemical genetic validation of CSNK2 substrates using an inhibitor-resistant mutant in combination with triple SILAC quantitative phosphoproteomics
Casein Kinase 2 (CSNK2) is an extremely pleiotropic, ubiquitously expressed protein kinase involved in the regulation of numerous key biological processes. Mapping the CSNK2-dependent phosphoproteome is necessary for better characterization of its fundamental role in cellular signalling. While ATP-c...
ORGANISM(S): Homo sapiens (Human) 
2022-07-14 | PXD033523 | Pride
Protein kinase ck2 U2os cells Csnk2 Silac Cx-4945 Phosphoproteomics Lc-ms/ms 
ProteomicsTriple SILAC identified progesterone-independent and dependent PRA and PRB interacting partners in human breast cancer cells
Progesterone receptor (PR) isoforms, PRA and PRB, both progesterone-independent and dependent modulated the biology of breast cancer cells. The different phenotypes in breast cancer mediated by PRA and PRB could due to the differences of their structures, leading to the distinct protein interacting ...
ORGANISM(S): Homo sapiens (Human) 
2021-03-08 | PXD023920 | Pride
Progesterone receptor Silac Breast cancer Interacting partners 
ProteomicsTriple SILAC based quantitative MS approach to determine Withaferin A regulated proteins in prostate cancer
Withaferin A (WA) is a lactone extracted from Withania somnifera commonly known as Ashwagandha. WA has several therapeutic benefits. The current study was aimed to identify biomarkers that could be targeted by WA in prostate cancer (PCA) cells. We have used SILAC approach to identify WA-regulated pr...
ORGANISM(S): Homo sapiens (Human) 
2021-07-21 | PXD016759 | Pride
Mass spectrometry Triple silac Du-145 Stress granule G3bp1 Prostate cancer Withaferin a Lncap 22rv1 
ProteomicsTriple SILAC glycoproteomic analysis of NSCLC cell lines
Protein glycosylation plays a fundamental role in a multitude of biological processes, and the associated aberrant expression of glycoproteins in cancer has made them attractive targets as biomarkers and therapeutic targets. In this study, we examined differentially expressed glycoproteins in cell l...
ORGANISM(S): Homo sapiens (Human) 
2015-12-10 | PXD001999 | Pride
Lung cancer Speg Glycoproteomics Silac 
UnknownTriple SILAC to determine stimulus specific interactions in the Wnt pathway.
Not available
S-EPMC3271738 | biostudies-literature
UnknownSILAC-based quantitative MS approach for real-time recording protein-mediated cell-cell interactions.
Not available
S-EPMC5981645 | biostudies-literature
ProteomicsGlobal phosphotyrosine survey reveals activation of multiple tyrosine kinase signaling pathways in triple negative breast cancer
About 15-20% of all breast cancers are triple negative breast cancers, which are often highly aggressive. We performed global quantitative phosphotyrosine profiling of a large panel of triple negative breast cancer cell lines using high resolution Fourier transform mass spectrometry. Our study ident...
ORGANISM(S): Homo sapiens (Human) 
2016-07-06 | PXD001222 | Pride
Tyrosine phosphorylation Phosphorylation Proteome Triple negative breast cancer 
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