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ProteomicsExtracellular Domain Shedding of TROP2 Activates EGFR Signaling to Drive Prostate Cancer Metastasis
Pull-down experiments were performed to characterize the interactome of the shed extracellular domain of TROP2 (TECD) in prostate cancer. Two independent strategies were used: (1) immunoprecipitation of TROP2 from patient sera, and (2) immunoprecipitation of DU145 cell lines treated with TECD. Prot...
ORGANISM(S): Homo sapiens (Human) 
2025-08-08 | PXD065965 | Pride
Trop2  tecd  prostate cancer  egfr  metastasis 
TranscriptomicsGene expression profiling of TROP2+ cells from human CRC (colorectal carcinoma) specimens
The Trophoblast cell surface antigen 2 (TROP2) is a transmembrane glycoprotein encoded by the Tumor associated calcium signal transducer 2 (TACSTD2) gene. TROP2 is upregulated in many human malignancies including colorectal cancer, and its overexpression correlates with tumor progression, invasivene...
ORGANISM(S): Homo sapiens 
2022-12-31 | E-MTAB-11466 | biostudies-arrayexpress
ProteomicsProteomics Analysis of Trop2 Xenograft Prostate Tumors
Shotgun proteomic analysis of LNCaP-Trop2-OV tumor xenografts and LNCaP-RFP control tumors
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2023-01-05 | PXD039272 | Pride
Prostate cancer Trop2 Xenograft Mice 
TranscriptomicsGene expression profiling of Trop2+ cells in mouse Apc-deficient small intestinal early adenomas
Tumor Associated Calcium Signal Transducer 2 (TACSTD2) is one of the cancer-related genes whose overexpression correlates with tumor progression and invasiveness in human colorectal cancer. TACSTD2 gene encodes for a transmembrane glycoprotein TROP2, which is implicated in altered expression of epit...
ORGANISM(S): Mus musculus 
2022-11-29 | E-MTAB-11382 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of Trop2+ cells in mouse Apc-deficient small intestinal hyperplastic epithelium
Tumor Associated Calcium Signal Transducer 2 (TACSTD2) is one of the cancer-related genes whose overexpression correlates with tumor progression and invasiveness in human colorectal cancer. TACSTD2 gene encodes for a transmembrane glycoprotein TROP2, which is implicated in altered expression of epit...
ORGANISM(S): Mus musculus 
2022-11-29 | E-MTAB-11377 | biostudies-arrayexpress
GenomicsGene expression profiling of Trop2+ and Trop2- luminal epithelial cells and stromal cells from young adult and old mouse prostates
Gene expression profiling of Trop2+ and Trop2- luminal epithelial cells and stromal cells from young adult and old mouse prostates
PRJNA528642 | ENA
GenomicsTROP2/claudin program mediates immune exclusion to impede checkpoint blockade in breast cancer
TROP2/claudin program mediates immune exclusion to impede checkpoint blockade in breast cancer
PRJNA1475339 | ENA
TranscriptomicsTROP2/claudin program mediates immune exclusion to impede checkpoint blockade in breast cancer
To investigate TROP2-dependent transcriptomic changes in breast cancer, we performed RNA-seq on frozen tumor sections from 4T1 Trop2 wild-type and Trop2 knockout tumors. This dataset was generated to define transcriptional programs regulated by TROP2 in the tumor microenvironment and to determine ho...
ORGANISM(S): Mus musculus 
2026-06-09 | GSE334497 | GEO
UnknownEpigenetically upregulating TROP2 and SLFN11 enhances therapeutic efficacy of TROP2 antibody drug conjugate sacitizumab govitecan.
Not available
S-EPMC10421911 | biostudies-literature
GenomicsGene expression profiling of Trop2+ cells in mouse Apc-deficient small intestinal early adenomas
Gene expression profiling of Trop2+ cells in mouse Apc-deficient small intestinal early adenomas
PRJEB50562 | ENA
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