Sort   by:  
 Page size 
ProteomicsCNNM proteins selectively bind to the TRPM7 channel to stimulate divalent cation entry into cells
Magnesium is essential for cellular life, but how it is homeostatically controlled still remains poorly understood. Here we report that members of CNNM family, which have been controversially implicated in both cellular Mg2+ influx and efflux, selectively bind to the TRPM7 channel to stimulate dival...
ORGANISM(S): Homo sapiens (Human) 
2021-11-15 | PXD026635 | Pride
Trpm7 cnnm3 cnnm4 cnmm2 
ProteomicsThe molecular appearance of native TRPM7 channel complexes identified by high-resolution proteomics
The transient receptor potential cation channel, subfamily M, member 7 (TRPM7) is a ubiquitously expressed membrane protein consisting of an ion channel domain and an intracellularly located protein kinase domain. TRPM7 plays a fundamental role in the cellular uptake of divalent cations such as Zn2+...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) Rattus norvegicus (Rat) 
2021-11-29 | PXD025279 | Pride
Ap-ms Lc-ms Csbn-ms Magnesium Cnnm Calcium Trpm7 Arl15 Zinc 
TranscriptomicsRNA-Seq data of Trpm7+/+ and Trpm7-/- embryonic stem cell clones
Partial exon deletion in Trpm7 gene was confirmed by lack of transcripts according to the RNA sequencing in two stem cell clones. For this mice were genetically modified by partial deletion of exon 2 and embryonic stem (ES) cell lines were generated. Isolated RNA of two ES clones was sequenced with ...
ORGANISM(S): Mus musculus 
2021-09-06 | E-MTAB-10877 | biostudies-arrayexpress
TranscriptomicsTRPM7 maintains progenitor-like features of neuroblastoma cells
Analysis of the effect of shRNA-mediated knockdown of TRPM7 on gene expression levels in SH-SY5Y and SH-EP2 human neuroblastoma cells. Results were used for the identification of neural-crest-associated transcription factors that were affected by TRPM7 knockdown. Total RNA isolated from SH-EP2 and S...
ORGANISM(S): Homo sapiens 
2014-12-10 | E-GEOD-64000 | biostudies-arrayexpress
TranscriptomicsExpression profiles from HEK293 cells by overexpression of TRPM7 channel
The functional activity of TRPM7 is essential for cell viability and growth, and its expression is up-regulated in certain pathological conditions. In order to assess the effects of TRPM7 activity on cellular gene expression, inducible HEK293 cell-lines harboring the wild-type mouse TRPM7 and a muta...
ORGANISM(S): Homo sapiens 
2011-07-22 | E-GEOD-23102 | biostudies-arrayexpress
GenomicsRNA-Seq data of Trpm7+/+ and Trpm7-/- embryonic stem cell clones
RNA-Seq data of Trpm7+/+ and Trpm7-/- embryonic stem cell clones
PRJEB47076 | ENA
GenomicsProfiling of villi transcriptome in Trpm7 gene deficient mice and control littermates.
Profiling of villi transcriptome in Trpm7 gene deficient mice and control littermates.
PRJNA434107 | ENA
GenomicsComplement Factor H maintains macrophage homeostasis through TRPM7 signaling
Complement Factor H maintains macrophage homeostasis through TRPM7 signaling
PRJNA1170995 | ENA
GenomicsEssential Role of Mg2+ for Mouse Preimplantation Embryo Development Revealed by TRPM7 Chanzyme Deficient Gametes
Essential Role of Mg2+ for Mouse Preimplantation Embryo Development Revealed by TRPM7 Chanzyme Deficient Gametes
PRJNA1008261 | ENA
TranscriptomicsTRPM7 maintains mesenchymal phenotype of breast cancer cells by tensional regulation of SOX4 (TRPM7 shRNA)
Analysis of the effect of shRNA-mediated knockdown of TRPM7 on gene expression levels in MDA-MB-231 human breast cancer cells. Results were used for the identification of so-called epithelial-mesenchymal transcription factors that were affected by TRPM7 knockdown and for the analysis of overlapping ...
ORGANISM(S): Homo sapiens 
2015-06-16 | GSE63956 | GEO
Sort   by:  
 Page size