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ProteomicsRegulation of mitochondrial oxidative phosphorylation and venetoclax efficacy in AML via COX4I1
Cell signaling pathways are enriched for biological processes crucial for cellular communication, response to external stimuli, and metabolism. Here, we conducted a cell signaling-focused CRISPR screen and identified cytochrome c oxidase subunit 4I1 (COX4I1) as a novel vulnerability in acute myeloid...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD050739 | Pride
Leukemia Cox4i1 Mitochondria 
MetabolomicsTargeting the SREBP-dependent lipidomic reprogramming by virus infection for broad-spectrum therapeutic intervention
Viruses are obligate intracellular parasites that exploit the host metabolic machineries to meet their extraordinary biosynthetic demands. Integrative transcriptomic and lipidomic profiling confirmed that Middle East respiratory syndrome coronavirus (MERS-CoV) infection reprograms the host lipid met...
2018-11-26 | MTBLS762 | MetaboLights
TranscriptomicsNormal colon top vs colon crypts
The study is to define the genetic programs of human colonic cell differentiation, and to identify candidate markers for colonic stem cells and stem cell niche The study assayed the expression of 9 paired normal colon top versus crypts. Set of arrays organized by shared biological context, such as o...
ORGANISM(S): Homo sapiens 
2007-08-28 | E-GEOD-6894 | biostudies-arrayexpress
ProteomicsProteomics analysis of mycobacterium marinum culture filtrate
Mycobacterium marinum is a pathogenic bacterium that causes infections in both fish and humans. The PE/PPE protein family is unique to mycobacteria and has been implicated in various aspects of mycobacterial pathogenicity. Understanding the presence and potential function of these proteins in M. mar...
ORGANISM(S): Mycobacterium marinum (strain ATCC BAA-535 / M) 
2025-05-13 | PXD050612 | Pride
Mycobacterium marinum Lc-ms Culture filtrate 
ProteomicsThe microenvironment dictates glyco-immune surveillance via HSF1-mediated metabolism
Efforts to identify anti-cancer therapeutics are attempted with in vitro models that do not match the microenvironmental characteristics of human tissues. Using biocompatible hydrogels that mimic healthy or cancerous tissues and conventional or physiologically relevant culture medium, we systematica...
ORGANISM(S): Homo sapiens (Human) 
2026-04-10 | PXD044309 | Pride
Ecm Metabolism Glycosylation Lc-ms/ms Mechanopharmacology 
ProteomicsIncreasing Proteome Coverage Through a Reduction in Analyte Complexity and Its Applications for Single-Cell Proteomics
The advancement of sophisticated instrumentation in mass spectrometry has catalyzed a more in-depth exploration of complex proteomes. This exploration necessitates a nuanced balance in experimental design, particularly between quantitative precision and the enumeration of analytes detected. In botto...
ORGANISM(S): Homo sapiens (Human) 
2024-07-17 | PXD048926 | Pride
Mass spectrometry Analyte complexity Proteomics 
UnknownComplex two-gene modulation of lung disease severity in children with cystic fibrosis.
Not available
S-EPMC2248329 | biostudies-literature
ProteomicsProteome alterations in MLL-rearranged leukemia cells following WIN Site inhibition
WIN Site inhibitors bind the WIN Site of WDR5 resulting in decreased transcription of WDR5 target genes, many of which encode components of the protein synthesis machinery. In this study, we determined proteome alterations in an MLL-rearranged leukemia cell line treated for either 24 or 72 hours wit...
ORGANISM(S): Homo sapiens (Human) 
2023-07-04 | PXD035129 | Pride
Proteomics Acute myeloid leukemia Ribosome Wdr5 Label-free quantification Chromatin Translation 
ProteomicsSystem-wide analyses reveal essential roles of N-terminal protein modification in bacterial physiology
Removal of the N-terminal formyl group on nascent proteins by peptide deformylase (PDF) is the most prevalent protein modification in bacteria that impacts over 90% of the proteome. PDF is essential and a critical target of antibiotic development; however, its role in bacterial physiology remains a ...
ORGANISM(S): Escherichia coli 
2022-07-20 | PXD032725 | Pride
Peptide deformylase N-terminal protein modification Membrane potential Mass spectrometry Ribosome profiling Protein biogenesis 
UnknownComparing Low- or Standard-Dose Alteplase in Endovascular Thrombectomy: Insights From a Nationwide Registry.
Not available
S-EPMC10896194 | biostudies-literature
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