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ProteomicsTTBK1/TTBK2 Phosphoproteomics in mouse cortical neurons
TTBK1 and TTBK2 unique substrate identifications in mouse cortical neurons through global phosphoproteomics studies. shRNA for both TTBK1 or TTBK2 was used to treat mouse cortical neurons, to knockdown each kinase.
ORGANISM(S): Mus musculus (Mouse) 
2025-05-06 | PXD017938 | Pride
Phosphoproteomics Shrna Neurons Ttbk2 Ttbk1 
TranscriptomicsTTBK2-Driven Ciliogenesis Is Required for Intrinsic Neuronal Regeneration after Spinal Cord Injury
Primary cilia (PCs) are microtubule-based organelles that function as critical signaling hubs in both embryonic neurodevelopment and mature neurons. Tau tubulin kinase 2 (TTBK2) is a key initiator of ciliogenesis, but its role in neuronal regeneration following spinal cord injury (SCI) remains uncle...
ORGANISM(S): Mus musculus 
2026-01-28 | GSE301749 | GEO
GenomicsTTBK2-Driven Ciliogenesis Is Required for Intrinsic Neuronal Regeneration after Spinal Cord Injury
TTBK2-Driven Ciliogenesis Is Required for Intrinsic Neuronal Regeneration after Spinal Cord Injury
PRJNA1287517 | ENA
ProteomicsPhosphorylation of multiple proteins involved in ciliogenesis by Tau Tubulin kinase 2
Abstract Primary cilia are organelles necessary for proper implementation of developmental and homeostasis processes. To initiate their assembly, coordinated actions of multiple proteins are needed. Tau tubulin kinase 2 (TTBK2) is a key player in the cilium assembly pathway, controlling final step o...
ORGANISM(S): Homo sapiens (Human) 
2020-03-25 | PXD014199 | Pride
Cep83 Cep89 Ccdc92 Mass spectrometry Phosphorylation Rabin8 Dvl3 Cep164 Ttbk2 
TranscriptomicsRegulation of Primary Cilia Disassembly Through HUWE1-Mediated TTBK2 Degradation Plays a Crucial Role in Cerebellar Development and Medulloblastoma Growth
Development of the cerebellum requires precise regulation of granule neuron progenitor (GNP) proliferation. Although it is known that primary cilia are necessary to support GNP proliferation, the exact molecular mechanism governing primary cilia dynamics within GNPs remains elusive. Here, we establi...
ORGANISM(S): Homo sapiens 
2024-06-03 | GSE268621 | GEO
UnknownTTBK2: a tau protein kinase beyond tau phosphorylation.
Not available
S-EPMC4407412 | biostudies-literature
GenomicsRegulation of Primary Cilia Disassembly Through HUWE1-Mediated TTBK2 Degradation Plays a Crucial Role in Cerebellar Development and Medulloblastoma Growth
Regulation of Primary Cilia Disassembly Through HUWE1-Mediated TTBK2 Degradation Plays a Crucial Role in Cerebellar Development and Medulloblastoma Growth
PRJNA1117916 | ENA
UnknownPhosphorylation of CEP83 by TTBK2 is necessary for cilia initiation.
Not available
S-EPMC6781440 | biostudies-literature
ProteomicsA novel TTBK2 missense variant causes loss of function and impaired protein phosphorylation: implications for spinocerebellar ataxia type 11
Spinocerebellar ataxia type 11 (SCA11) is a rare form of autosomal dominant cerebellar ataxia, characterized by a relatively slow progression and normal life expectancy. However, it is a highly debilitating disorder. In 2007, SCA11 was genetically linked to TTBK2, which encodes tau tubulin kinase 2 ...
ORGANISM(S): Homo sapiens (Human) 
2025-12-22 | PXD056662 | Pride
Spinocerebellar ataxia type 11 (sca11)  tau-tubulin kinase 2 (ttbk2)  crispr/cas9  kinase activity  phosphoproteomics  cytoskeleton 
UnknownModulation of tau tubulin kinases (TTBK1 and TTBK2) impacts ciliogenesis.
Not available
S-EPMC10104807 | biostudies-literature
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