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GenomicsThe NF-kB genomic landscape in lymphoblastoid B-cells
The nuclear factor kB (NF-kB) subunits RelA, RelB, c-Rel, p50 and p52 are each critical for B-cell development and function. To systematically characterize their responses to canonical and non-canonical NF-kB pathways activity, we performed ChIP-seq analysis in lymphoblastoid B-cells. We found a su...
ORGANISM(S): Homo sapiens 
2014-08-29 | E-GEOD-55105 | biostudies-arrayexpress
ProteomicsMutations and variants of ONECUT1 in diabetes
Genes involved in distinct diabetes types suggest shared disease mechanisms. We show that rare ONECUT1 coding variants cause monogenic recessive diabetes (neonatal or very early-onset, syndromic) in two unrelated patients, and monogenic dominant diabetes (early adult-onset) in heterozygous relatives...
ORGANISM(S): Homo sapiens (Human) 
2021-11-03 | PXD018887 | Pride
Differentiation Stem cells Onecut1 Proteomics 
ProteomicsInhibiting Mrt4-rRNA interaction with fumaramidmycin-based derivatives as an unexploited antifungal strategy
The rise of drug resistance and limitations of current antifungal treatments highlight the urgent need for innovative antifungal strategies. Here we present the development of cis-fumaramidmycin-derived analogues as a novel chemotype inhibiting the interactions of ribosome assembly factor Mrt4 with ...
ORGANISM(S): Candida albicans (Yeast) 
2026-04-27 | PXD068797 | Pride
Invasive fungal infections Protein-rna interaction covalent inhibitors Fumaramidmycin derivatives Ribosome assembly factor mrt4 Antifungal target identification 
ProteomicsInhibiting Mrt4-rRNA interaction with fumaramidmycin-based derivatives as an unexploited antifungal strategy-qualitative proteomic
The rise of drug resistance and limitations of current antifungal treatments highlight the urgent need for innovative antifungal strategies. Here we present the development of cis-fumaramidmycin-derived analogues as a novel chemotype inhibiting the interactions of ribosome assembly factor Mrt4 with ...
ORGANISM(S): Candida albicans (Yeast) 
2026-04-27 | PXD073550 | Pride
Ribosome assembly factor Azole-resistant fungi Protein-rna interaction Fumaramidmycin-based derivatives Target identification 
ProteomicsIdentify UFM1 targeted protein
we want to identify UFM1 target protein in human cells
ORGANISM(S): Homo sapiens (Human) 
2019-04-02 | PXD012729 | Pride
293t cell Ufm1 Human 
ProteomicsHuman pancreatic cancer LC-MSMS
This project aims to research protein-protein interaction of pancreatic cancer cells under different DNA replication pressure.
ORGANISM(S): Homo sapiens (Human) 
2022-09-20 | PXD032951 | Pride
Human Lc-msms Pancreatic cancer cells 
ProteomicsIdentification of ELOB interacting proteins by LC-MS/MS
To identify proteins that interact with ELOB (TCEB2) in mouse multiple tissues, including brain, fat, heart, intestine, liver, lung, ovary, spleen, stomach, testis, and uterus. Immunocoprecipitation (IP) experiments were performed and subjected to LC-MS/MS analysis and Label-free quantification.
ORGANISM(S): Mus musculus (Mouse) 
2026-02-13 | PXD064743 | Pride
Ip Elob Mouse Lc-ms/ms 
ProteomicsIdentification of ASB9 interacting proteins by LC-MS/MS
To determine the proteins that interact with ankyrin repeat and SOCS box-containing 9 (ASB9) in mouse testes, two separate immunocoprecipitation (IP) experiments were carried out. The samples from these experiments were then analyzed by LC-MS/MS and underwent Label-free quantification.
ORGANISM(S): Mus musculus (Mouse) 
2026-02-13 | PXD064742 | Pride
Asb9 Ip Mouse Lc-ms/ms 
UnknownThe Draft Genome of the Endangered Sichuan Partridge (Arborophila rufipectus) with Evolutionary Implications.
Not available
S-EPMC6770966 | biostudies-literature
TranscriptomicsInactivation of Oncogenic cAMP-specific Phosphodiesterase 4D by miR-139-5p in Response to p53 Activation
Investigation of microRNA expression level changes in human colon cancer cell lines in response to p53 activation by Inauhzin (INZ), and identification of novel p53 target microRNAs. HCT116 p53+/+ and HCT116 p53-/- cells were treated with DMSO or 4μM INZ and harvested at 18 hours post treatment. Ce...
ORGANISM(S): Homo sapiens 
2016-07-20 | E-GEOD-79099 | biostudies-arrayexpress
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