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MetabolomicsQuantitative metabolomics of plasma and tissue interstitial fluids from mice

This study presents quantitative metabolomic measurements of plasma and tissue interstitial fluids (IF) collected from healthy C57BL/6J mice. Using liquid chromatography–mass spectrometry (LC–MS) and external chemical standards, absolute concentrations were determined for over one hundred polar m...

2025-12-30 | MTBLS13165 | MetaboLights
ProteomicsEvaluation of tumor interstitial fluid-extraction methods for proteome analysis: comparison of biopsy elution versus centrifugation
The analysis of Tumor Interstitial Fluid (TIF) composition is a valuable procedure to identify anti-metastatic targets, and different laboratories have set up techniques for TIF isolation and proteomic analyses. However, those methods had never been compared in samples from the same tumor and patien...
ORGANISM(S): Homo sapiens (Human) 
2020-05-06 | PXD016261 | Pride
Cutaneous squamous cell carcinoma Skin cancer Tumor interstitial fluid Spin Proteome Centrifugation Elution 
ProteomicsPeptide profiles in interstitial fluid of breast cancer samples with high or low CD10+ CAF infiltration
To investigate whether CD10 in CAFs exerts its functions by mediating peptide degradation, we applied a high performance liquid chromatography with tandem mass spectrometry (HPLC-MS/MS)-based approach to compare peptide profiles in interstitial fluid of breast cancer samples with high or low CD10+ C...
ORGANISM(S): Homo sapiens (Human) 
2022-02-16 | PXD021590 | Pride
Breast cancer Lc-msms Human Tumor interstitial fluid 
MetabolomicsAggressive breast cancers secrete heme metabolites to alter macrophage immune suppression and function
The heme catabolism pathway is often elevated in aggressive cancers; however, the impact of this pathway and some of its byproducts on the tumor microenvironment remain largely unknown. In human breast cancers, tumor expression of the heme catabolizing enzyme heme oxygenase-1 (HO-1/HMOX1) is positiv...
2026-04-24 | MTBLS14278 | MetaboLights
ProteomicsProteomic profiling of paired interstitial fluids revealed dysregulated pathways and salivary NID1 as a biomarker of oral cavity squamous cell carcinoma
Patients with oral cavity squamous cell carcinoma (OSCC) are frequently first diagnosed at an advanced stage, leading to poor prognosis and high mortality rate. Early detection of OSCC using body fluid-accessible biomarkers may help improve the prognosis and survival rate of OSCC patients. As tumor ...
ORGANISM(S): Homo sapiens (Human) 
2019-08-15 | PXD008654 | Pride
Tumor interstitial fluid Saliva Oral cavity squamous cell carcinoma Aminoacyl trna biosynthesis Nidogen-1 Biomarker 
ProteomicsCathepsin B and Cathepsin Z tumor secretome of murine breast cancers
MS-based proteomics study of the cancer secretome and tumor interstitial fluid of tumor cell/macrophage co-cultures and breast tumors in cells and mice lacking both cathepsin B and cathepsin Z
ORGANISM(S): Mus musculus (Mouse) 
2021-09-08 | PXD015209 | Pride
Tumor interstitial fluid Ccm Mouse Secretome 
ProteomicsBiomarkers found in the tumor interstitial fluid may help explain the differential behavior among keratinocyte carcinomas
Keratinocyte carcinomas (KC) are the most common malignancy worldwide. This category of tumours groups both basal (BCC) and squamous (SCC) cell carcinomas. While the former rarely metastasizes (0.03-0.55%), the latter is more associated to a substantial risk of local recurrence, metastasis and death...
ORGANISM(S): Homo sapiens (Human) 
2023-04-14 | PXD036900 | Pride
Orbitrap dusion lumos Basal cell carcinoma Squamous cell carcinoma Tumor interstitial fluid Label free 
GenomicsEffect of pancreatic tumor interstitial fluid media on transcriptional responses in PDAC cells
Effect of pancreatic tumor interstitial fluid media on transcriptional responses in PDAC cells
PRJNA1425608 | ENA
TranscriptomicsscRNA-seq analysis of cell subpopulations of the bronchoalveolar lavage fluid of healthy dogs
In dogs, a species for which markers of cell populations are often limiting, we sought to evaluate in an unbiased way the heterogeneity of cell subpopulations in the bronchoalveolar lavage fluid of healthy dogs, by single-cell RNA-sequencing.
ORGANISM(S): Canis lupus familiaris 
2020-06-29 | E-MTAB-9265 | biostudies-arrayexpress
TranscriptomicsEMT Alters Interstitial Fluid Flow-induced Signaling in ERBB2-positive Breast Cancer
A variety of mechanotransduction forces are altered in the tumor microenvironment (TME) and these biophysical forces can influence cancer progression. One such force is interstitial fluid flow (IFF) - the movement of fluid through the tissue matrix. IFF was previously shown to induce invasion of can...
ORGANISM(S): Homo sapiens 
2015-01-06 | E-GEOD-64670 | biostudies-arrayexpress
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