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TranscriptomicsCellular Transcriptional Responses to Merkel cell polyomavirus T antigens
Merkel cell polyomavirus (MCV) is clonally integrated in over 80% of Merkel cell carcinomas and mediates tumor development through the expression of viral oncoproteins large T (LT) and small T antigens (sT). Viral integration is associated with signature mutations in the T antigen locus that result ...
ORGANISM(S): Homo sapiens 
2015-09-21 | E-GEOD-68503 | biostudies-arrayexpress
ProteomicsAcute lymphoblastic leukemia in children produces endogenous T-cells targeting tumor associated antigens and neoantigens in peripheral blood
In this study we investigated the presence of endogenous T-cells recognizing private tumor-associated antigens and predicted neoantigens. To this end, HLA-I and HLA-II restricted tumor associated antigens (TAAs) and neoantigens were respectively identified and predicted. Of interest, circulating T-c...
ORGANISM(S): Homo sapiens (Human) 
2025-07-14 | PXD061914 | Pride
Human Pediatric leukemia Mass spectrometry Antigen discovery 
TranscriptomicsTranscriptomic Analysis Comparing Tumor-Associated Neutrophils with Granulocytic Myeloid-Derived Suppressor Cells and Normal Neutrophils
The role of myeloid cells in supporting cancer growth is well established. Most work has focused on myeloid-derived suppressor cells (MDSC) that accumulate in tumor-bearing animals, but tumor-associated neutrophils (TAN) are also known to be capable of augmenting tumor growth. However, little is kno...
ORGANISM(S): Mus musculus 
2013-01-04 | E-GEOD-43254 | biostudies-arrayexpress
ProteomicsMapping the soluble human leukocyte antigen peptidome of pleural effusions reveals lung and tumor-associated antigens
Soluble HLA (sHLA) molecules released to the plasma, carry their original peptide cargo and provide insight into the protein synthesis and degradation schemes of their source cells and tissues. Other body fluids, such as pleural effusions, may also contain sHLA-peptide complexes, and can potentially...
ORGANISM(S): Homo sapiens (Human) 
2022-05-25 | PXD027766 | Pride
Tumor antigens Immunopeptisome Pleural effusion Cancer/testis antigens Hla peptidome Lung cancer Lc-ms/ms 
ProteomicsUnveiling novel tumor-associated antigens to overcome diagnostic challenges in barely seroreactive colorectal cancer patients using mass spectrometry-based proteomics
The humoral immune response plays a critical role in cancer immune surveillance, producing autoantibodies against tumor-associated antigens (TAAs). These autoantibodies show potential as non-invasive biomarkers for early cancer detection in colorectal cancer (CRC), a leading cause of cancer-related ...
ORGANISM(S): Homo sapiens (Human) 
2026-09-21 | PXD076609 | Pride
Autoantibodies Immunoaffinity purification Liquid biopsy Dia mass spectrometry Seroproteomics Colorectal cancer (crc) Tumor-associated antigens (taas) Biomarker discovery 
ProteomicsCIITA-transduced glioblastoma cells uncover a rich repertoire of clinically relevant tumor-associated HLA-II antigens
CD4+ T cell responses are crucial for inducing and maintaining effective anti-cancer immunity, and the identification of HLA-II cancer-specific epitopes is key to the development of potent cancer immunotherapies. In many tumor types, and especially in glioblastoma (GBM), HLA-II complexes are hardly ...
ORGANISM(S): Homo sapiens (Human) 
2021-02-03 | PXD020079 | Pride
Glioblastoma Immunopeptidomics Antigen presentation Ciita 
TranscriptomicsIdentification of breast cancer tumor associated antigens
Four prototypic situations, corresponding to progressive stages of mammary carcinogenesis, were analyzed. Total RNA from whole-mount for 10, 15, 19 and 22 weeks old BALB-neuT animals was extracted. Differential expression between the various prototypic conditions indicates the presence of changing i...
ORGANISM(S): Mus musculus 
2007-04-19 | GSE7395 | GEO
ProteomicsUpstream open reading frames regulate proto-oncogene translation and encode HLA-presented immunogenic tumor antigens
Upstream open reading frames (uORFs) represent translational control elements within eukaryotic transcript leader sequences. Recent data showed that uORFs can encode for biologically active proteins and human leucocyte antigen (HLA)-presented peptides and suggest their potential role in cancer cell ...
ORGANISM(S): Homo sapiens (Human) 
2022-04-04 | PXD025716 | Pride
Cancer Uorf Immunotherapy Immunopeptidomics Hla peptides 
UnknownIdentification and validation of viral antigens sharing sequence and structural homology with tumor-associated antigens (TAAs).
Not available
S-EPMC8166618 | biostudies-literature
UnknownA high throughput method for identifying personalized tumor-associated antigens.
Not available
S-EPMC2920534 | biostudies-literature
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