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ProteomicsER stress and dsRNA sensing with Rt3D and palbociclib - Immunopeptidome
Cytoplasmic pattern recognition receptors (PRRs) for double-stranded RNA (RIG-I/MDA5) are key mediators of anti-viral responses. PRR agonists, such as dsRNA oncolytic Reovirus type 3 Dearing (Rt3D), potently activate RNA sensors. We used an unbiased cytotoxicity screen to reveal synergistic drug-vir...
ORGANISM(S): Homo sapiens (Human) 
2025-05-02 | PXD036559 | Pride
A375 Tmtpro Immunopeptidome 
ProteomicsER stress and dsRNA sensing with Rt3D and palbociclib - Whole Proteome
Cytoplasmic pattern recognition receptors (PRRs) for double-stranded RNA (RIG-I/MDA5) are key mediators of anti-viral responses. PRR agonists, such as dsRNA oncolytic Reovirus type 3 Dearing (Rt3D), potently activate RNA sensors. We used an unbiased cytotoxicity screen to reveal synergistic drug-vir...
ORGANISM(S): Homo sapiens (Human) 
2025-05-02 | PXD036540 | Pride
Human A375 Proteome Tmt 
ProteomicsPARP inhibitors enhance reovirus-mediated cell killing through the death-inducing signaling complex (DISC) with an associated NF-B-regulated immune response.
Oncolytic Reovirus type 3 Dearing (RT3D), is a naturally occurring double-stranded (ds) RNA virus that is under development as an oncolytic immunotherapy We used an unbiased high-throughput cytotoxicity screen of different targeted therapeutic agents with the aim of identifying potential drug-viral ...
ORGANISM(S): Homo sapiens (Human) 
2025-05-01 | PXD047621 | Pride
Reovirus Parp inhibition Proteome Death inducing signaling complex (disc) Rig-i Nf-b Oncolytic virus Tmt Talazoparib Ifn Reovirus Type 3 dearing (rt3d) Cancer 
GenomicsER stress and dsRNA sensing with Rt3D and palbociclib
CDK4/6 inhibition and dsRNA sensor agonism co-operate to enhance anti-cancer effects through ER stress and immune modulation of tumour cells
PRJEB75360 | ENA
UnknownBRAF- and MEK-Targeted Small Molecule Inhibitors Exert Enhanced Antimelanoma Effects in Combination With Oncolytic Reovirus Through ER Stress.
Not available
S-EPMC4427871 | biostudies-literature
UnknownEnhanced cytotoxicity of reovirus and radiotherapy in melanoma cells is mediated through increased viral replication and mitochondrial apoptotic signalling.
Not available
S-EPMC5217035 | biostudies-literature
ProteomicsMechanisms of therapeutic synergy between pattern recognition response agonists and cdk4 inhibitors
Cytoplasmic nucleic acid sensors for double-stranded (ds) RNA (RIG-I/MDA5) and DNA (cGAS-STING) are pattern recognition receptors (PRRs) key to intracellular anti-viral responses. Recent research has highlighted roles for PRR agonists, including oncolytic virotherapy agents, in anti-tumor immunother...
ORGANISM(S): Homo sapiens (Human) 
2026-06-22 | PXD022642 | Pride
Cancer Rnavirus Tmt Palbociclib 
UnknownPhase I/II trial of carboplatin and paclitaxel chemotherapy in combination with intravenous oncolytic reovirus in patients with advanced malignancies.
Not available
S-EPMC5553618 | biostudies-literature
UnknownPhase I trial of cyclophosphamide as an immune modulator for optimizing oncolytic reovirus delivery to solid tumors.
Not available
S-EPMC4821068 | biostudies-literature
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